Effect of Pterocarpus marsupium in animal model of high carbohydrate diet-induced metabolic syndrome
Journal Title: National Journal of Physiology, Pharmacy and Pharmacology - Year 2018, Vol 8, Issue 11
Abstract
Background: Metabolic syndrome (MS) is a group of interconnected disorder linked to obesity, insulin resistance hypertension, and dyslipidemia. It is a risk factor for the development of Type II diabetes and cardiovascular diseases. Thus, there is a need to search for therapeutic options for the treatment of MS. Aims and Objective: The present study was conducted to evaluate the protective effect of Pterocarpus marsupium (Bijasar) in animal model of high carbohydrate diet-induced MS. Materials and Methods: Adult male Wistar rats were divided into three groups. All the animals were given 20% sucrose in drinking water ad libitum for 8 weeks for the induction of MS along with the following treatment. Group I (Control): Distilled water; Group II (PM group): Aqueous extract of P. marsupium (200 mg/kg/day); and Group III (Standard treatment): Metformin 100 mg/kg/day + Atorvastatin 10 mg/kg/day. Body weight, abdominal circumference (AC), blood glucose, and serum triglycerides were evaluated at the end of 4 weeks and 8 weeks. Results: The aqueous extract of P. marsupium at a dose of 200 mg/dl caused a significant reduction (P < 0.05) in the body weight, AC, blood sugar and serum triglyceride levels when compared to the control group. Similar results were seen in the standard treatment group. Conclusion: PM was effective in the treatment of major components of MS in rat model of high carbohydrate diet-induced MS.
Authors and Affiliations
Fardan Qadeer, Afroz Abidi, Fariha Fatima, Dilshad Ali Rizvi
Keywords
Related Articles
- EP ID EP497857
- DOI 10.5455/njppp.2018.8.0826011082018
- Views 96
- Downloads 0
Impact of stroke on quality of life and functional independence
Background: Cerebrovascular accident is the prime cause for the functional disability and deteriorated quality of life (QOL) which affects person’s social and physical capabilities. Present stroke outcomes are restricted...
Comparison of bleeding time and clotting time between males and females
Background: Bleeding time (BT) depends on various factors such as functions of platelets and endothelial cells of arteries and pathways of coagulation. Clotting time (CT) is increased due to the absence or abnormality of...
Factors contributing to development of multidrug resistant tuberculosis
Background: Several factors have been identified in the causation of multidrug-resistant tuberculosis (MDR-TB). The most important is previous inadequate treatment. Other factors include coinfection with HIV, diabetes me...
Effect of Balasana on cardiac parameters among healthy medical students
Background: Among many professional courses, MBBS found to be difficult to complete, where students are busy with studies throughout the course. They have less chances of relaxation. Sage Patanjali explained two limbs of...