Effect of Pterocarpus marsupium in animal model of high carbohydrate diet-induced metabolic syndrome
Journal Title: National Journal of Physiology, Pharmacy and Pharmacology - Year 2018, Vol 8, Issue 11
Abstract
Background: Metabolic syndrome (MS) is a group of interconnected disorder linked to obesity, insulin resistance hypertension, and dyslipidemia. It is a risk factor for the development of Type II diabetes and cardiovascular diseases. Thus, there is a need to search for therapeutic options for the treatment of MS. Aims and Objective: The present study was conducted to evaluate the protective effect of Pterocarpus marsupium (Bijasar) in animal model of high carbohydrate diet-induced MS. Materials and Methods: Adult male Wistar rats were divided into three groups. All the animals were given 20% sucrose in drinking water ad libitum for 8 weeks for the induction of MS along with the following treatment. Group I (Control): Distilled water; Group II (PM group): Aqueous extract of P. marsupium (200 mg/kg/day); and Group III (Standard treatment): Metformin 100 mg/kg/day + Atorvastatin 10 mg/kg/day. Body weight, abdominal circumference (AC), blood glucose, and serum triglycerides were evaluated at the end of 4 weeks and 8 weeks. Results: The aqueous extract of P. marsupium at a dose of 200 mg/dl caused a significant reduction (P < 0.05) in the body weight, AC, blood sugar and serum triglyceride levels when compared to the control group. Similar results were seen in the standard treatment group. Conclusion: PM was effective in the treatment of major components of MS in rat model of high carbohydrate diet-induced MS.
Authors and Affiliations
Fardan Qadeer, Afroz Abidi, Fariha Fatima, Dilshad Ali Rizvi
Keywords
Related Articles
- EP ID EP497857
- DOI 10.5455/njppp.2018.8.0826011082018
- Views 67
- Downloads 0
Learning strategies in medical school: A holistic approach to physiology
Background: In medical college medical curriculum needs to be evaluated on a regular basis because students perception about the subjects should be known to the teachers. Assessment of medical students regarding the unde...
Nootropic activity of ethanolic extract of Alangium salvifolium leaves on Scopolamine mouse model of Alzheimer’s disease
Background: Alangium salvifolium possesses completely different medicine activities such as antioxidant, anticancer, antiinflammatory, bactericide, antifungal, and antifertility. It is also employed in the treatment of a...
Evaluation of efficacy of jaggery and raisins as supplements in iron deficiency anemia among medical undergraduate students in South India
Background: Anemia is defined as a reduction of the total circulating red cell mass and is a major public health problem in India. More than 1.6 billion anemic people have manifestations of iron deficiency anemia (IDA)....
Description of physical fitness, blood glucose, and cholesterol levels of the middle age operational workers in transportation company
Background: Physical fitness (PF) is a key to maintain company productivity. The transportation company has complicated jobs and high physical demand. Aging, obesity, and sedentary lifestyle can decrease PF and work prod...
Detecting the neurogenesis effect of erythropoietin and galantamine in the dentate gyrus and spatial memory in Alzheimer’s experimental rat model
Background: Alzheimer’s disease is neurodegenerative disorder develops unreversed causing memory and behavior impairment. It is estimated that 35.5 million people are living with Alzheimer’s disease worldwide. The early...