Effect of Pterocarpus marsupium in animal model of high carbohydrate diet-induced metabolic syndrome
Journal Title: National Journal of Physiology, Pharmacy and Pharmacology - Year 2018, Vol 8, Issue 11
Abstract
Background: Metabolic syndrome (MS) is a group of interconnected disorder linked to obesity, insulin resistance hypertension, and dyslipidemia. It is a risk factor for the development of Type II diabetes and cardiovascular diseases. Thus, there is a need to search for therapeutic options for the treatment of MS. Aims and Objective: The present study was conducted to evaluate the protective effect of Pterocarpus marsupium (Bijasar) in animal model of high carbohydrate diet-induced MS. Materials and Methods: Adult male Wistar rats were divided into three groups. All the animals were given 20% sucrose in drinking water ad libitum for 8 weeks for the induction of MS along with the following treatment. Group I (Control): Distilled water; Group II (PM group): Aqueous extract of P. marsupium (200 mg/kg/day); and Group III (Standard treatment): Metformin 100 mg/kg/day + Atorvastatin 10 mg/kg/day. Body weight, abdominal circumference (AC), blood glucose, and serum triglycerides were evaluated at the end of 4 weeks and 8 weeks. Results: The aqueous extract of P. marsupium at a dose of 200 mg/dl caused a significant reduction (P < 0.05) in the body weight, AC, blood sugar and serum triglyceride levels when compared to the control group. Similar results were seen in the standard treatment group. Conclusion: PM was effective in the treatment of major components of MS in rat model of high carbohydrate diet-induced MS.
Authors and Affiliations
Fardan Qadeer, Afroz Abidi, Fariha Fatima, Dilshad Ali Rizvi
Keywords
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- EP ID EP497857
- DOI 10.5455/njppp.2018.8.0826011082018
- Views 78
- Downloads 0
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