Effect of RAGE -429T / C and Gly82Ser Gene Polymorphism in Diabetic Retinopathy in General Hospital Mohammad Hoesin Palembang
Journal Title: Journal of Research in Medical and Dental Science - Year 2017, Vol 5, Issue 5
Abstract
The development of diabetic retinopathy varies in a number of populations, suggesting genetic factors contribute to its pathogenesis, compatible with the severity of hyperglycemia that occurs. One of the underlying theories is the increased glycosylation of enzymatic proteins that are irreversible to the formation of AGE. To know is there any effect of RAGE Genetic allele polymorphism in diabetics retinopathy in General Hospital Mohammad Hoesin Palembang. This study was an observational analytical study comparative study (case control study) on 90 subjects consisting of 30 people with type 2 diabetes with retinopathy, 30 people with DM without retinopathy and 30 normal control people who had a family relationship with case group. Frequency of RAGE -429T / C & Gly82Ser alelle gene is performed by PCR amplification and RFLP (Restriction Fragment Length Polymorphism) by using Alu1 enzyme. Frequency of C alleles is 20% from the DR group, 15% from the DNR, and 5% from control group. Odds Ratio was 7,85 with p = 0.028. Frequency of wild genotype alleles in the Gly82Ser RAGE gene was found 40% in DR, 53.33% in DNR, 70% in control group, whereas the mutant allele were 60% in DR, 46.67% in DNR, 30% in control group. Frequency of Gly allele is 70% in DR, 23% in DNR, 85% in control group and frequency of Ser DR allele (30%), RND (70%), 15% in control group, Chi Square test with p = 0.065, α=0.05, Odds Ratio 5,57, CI: 95%. There is the effect of variant RAGE -429T / C and Gly82Ser allele polymorphism in diabetic retinopathy patients.
Authors and Affiliations
Riani Erna, Dharma Sastrawan, Irsan Saleh
Keywords
Related Articles
- EP ID EP308995
- DOI -
- Views 120
- Downloads 0
Evaluating the association between first trimester screening tests and adverse perinatal outcomes
Prenatal screening tests are not diagnostic and only show and determine the risk of fetal abnormalities. This study aimed to evaluate the association between the results of double marker test and nuchal translucency (NT)...
A rare presentation of Retiform Hemangioendothelioma in sacral area
Retiform Hemangioendothelioma is an extremely rare tumor. It was first explained by Calonje et al in 1994. It is a vascular neoplasm of borderline malignancy, mostly seen in young age, and extremities. A 65 years old fem...
The Role of Occupational Stress in Prediction of Marital Satisfaction among Married Nurses Occupied at Shahid Motahari Hospital, Jahrom
This study is aimed to explain the role of stress in prediction of marital satisfaction among married nurses occupied at Shahid Motahari Hospital, Jahrom, Iran. This research, in terms of nature and objectives, is an app...
Effect of Aqueous-alcoholic Extract of Aloe vera on Retinal Tissue Changes in Rats with Experimental Multiple Sclerosis
Multiple Sclerosis is a chronic inflammatory disease of the central nervous system and demyelination of the central and the peripheral nerves, axonal damage and their loss are considered as the most important symptoms of...
Prevalence of Home Accidents among 0-6-Year Old Children Mothers’ Levels of Displaying Precaution-Taking Behaviors
In this study was aimed at determining the prevalence of home accidents among 0-6-year-old children living in rural area in the city center of Balikesir within the past two weeks, their mothers’ levels of displaying prec...