Effect of repeated co-treatment with imipramine and metyrapone on the behavioral reactivity of the central serotonin, dopamine and alpha(1)-adrenergic systems in rats.
Journal Title: Pharmacological Reports - Year 2007, Vol 59, Issue 5
Abstract
The aim of present study was to examine the effect of repeated co-treatment with imipramine and metyrapone on the development of adaptive changes in the function of central serotonin 5-HT(1A) and 5-HT(2A), dopamine D(2/3) and alpha(1)-adrenergic receptors in rats. The obtained results showed that repeated co-treatment with imipramine (5 or 10 mg/kg) and metyrapone (50 mg/kg) (twice daily for 14 days) either induced more potent inhibition of the behavioral syndrome evoked by 5-HT(1A) and 5-HT(2A) receptor agonists (8-OH-DPAT and (+/-)DOI, respectively), or did no change the action of amphetamine and wuinpirole (a dopamine D(2/3) agonist) or phenylephrine (an alpha(1)-adrenergic agonist) compared to treatment with either drug alone. The results described in the present paper support the hypothesis that repeated co-treatment with imipramine and metyrapone may possess more effective antidepressant activity than the treatment with imipramine alone, and that, among other mechanisms, 5-HT(1A)- and 5-HT(2A) (but not dopamine D(2/3)- or alpha(1)-adrenergic) receptors may also play some role in this effect.
Authors and Affiliations
Zofia Rogóż
Keywords
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