Effect of repeated restraint on homotypic stress-induced nitric oxide synthases expression in brain structures regulating HPA axis.
Journal Title: Pharmacological Reports - Year 2012, Vol 64, Issue 6
Abstract
Restraint stress (RS) markedly increases interleukin 1-β (IL-1β) generation in brain structures involved in hypothalamic-pituitary adrenocortical (HPA) axis regulation. The IL-1β-induced transient stimulation of HPA axis activity was parallel in time and magnitude to respective changes in regulation of HPA activity. In the present experiment the expression of neuron al and inducible nitric oxide synthase (nNOS and iNOS) were investigated in prefrontal cortex, hippocampus and hypothalamus in response to acute restraint stress in control and prior repeatedly restrained rats.
Authors and Affiliations
Anna Gądek-Michalska, Joanna Tadeusz, Paulina Rachwalska, Jadwiga Spyrka, Jan Bugajski
Keywords
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