Effect of Resistance Exercise Training Associated with Skeletal Muscle Hypertrophy on Serum Pro-Inflammatory Cytokines in STZ-induced Diabetes
Journal Title: International Journal of Medical Research & Health Sciences (IJMRHS) - Year 2016, Vol 5, Issue 6
Abstract
Skeletal muscle atrophy is associated with type 1 diabetes. Effects of resistance exercise training associated with skeletal muscle hypertrophy on serum inflammatory cytokines was exactly not clarified. Protein levels of inflammatory cytokines IL-6, TNF-α, and interleukin-1beta (IL-1β) in serum of healthy and streptozotocin (STZ)- induced diabetic rats subjected to resistance exercise training were assessed in this study. Rats were divided into the control, training, control diabetic and diabetic training groups. Training groups performed the resistance training consisted of climbing a 1 m ladder with increasing weight added to the tail. Proteins levels of IL-6, TNF-α and IL-1β in serum were measured by the ELIZA method. The results of this study indicated that resistance training induced skeletal muscle hypertrophy in diabetic samples (P<0.05). Also, Resistance training decrease IL-6 protein levels in serum. Inflammatory cytokines could act as stress factors in diabetes. It seems that this kind of exercise training individually could not change cytokines levels in serum.
Authors and Affiliations
Mahdieh Molanouri Shamsi| Departmentof Physical Education & Sport Sciences, Taft Branch, Islamic Azad University, Taft, Iran, Mohsen Fallah| Department of Physical Education & Sport Sciences, Taft Branch, Islamic Azad University, Taft, Iran, Corresponding Email: Mahdieh_molanouri@yahoo.com, Mohammad Ghaderi| Department of Physical Education & Sport Sciences, Mahabad Branch, Islamic Azad University, Mahabad, Iran
Keywords
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