EFFECT OF ROTATORY VESTIBULAR STIMULATION ON LEARNING AND MEMORY IN RATS-STANDARDIZATION OF A NOVEL METHOD
Journal Title: International Journal of Pharmacy and Pharmaceutical Sciences - Year 2017, Vol 9, Issue 1
Abstract
Objective: To find out the effect of rotatory vestibular stimulation in cognition in rats through examining the behavioural patterns, the alterations in dendritic arborization and changes in AChE activity.Methods: Rotatory vestibular stimulation was provided in a rotatory vestibular apparatus at a rate of 50 rpm for 5 min, for 30 d for rats. 0.3 mg/kg of physostigmine also administered to rats of another group as a standard drug. No rotatory vestibular stimulation or physostigmine is provided to the control rats. Behavioural analysis, Neuromorphological and biochemical studies were done after vestibular stimulation.Results: No. of trails for acquisition and retention reduced significantly in treated rats when compared with the control rats. In all the treated rats the dendritic arborization increased significantly, and activity of AChE decreased significantly when compare with the control.Conclusion: Rotatory vestibular stimulation enhances learning and memory via increasing dendritic arborization and inhibiting acetyl-cholinesterase activity in rats.Â
Authors and Affiliations
Devi N. P. , J. K. Mukkadan
Keywords
Related Articles
- EP ID EP575785
- DOI 10.22159/ijpps.2017v9i1.14940
- Views 61
- Downloads 0
ANTIMICROBIAL PROPERTIES OF LEPTADENIA HASTATA (PERS) DECNE LEAVES EXTRACT
Objective: This study was carried out with an objective to investigate the antibacterial potential of five leaf extract of Leptadenia hastata plant on some bacteria.Methods: Leptadenia hastata extracts were evaluated for...
EVALUATION OF ANTIHYPERLIPIDEMIC, ANTI-INFLAMMATORY, AND ANALGESIC ACTIVITIES OF EURYCOMA LONGIFOLIA IN ANIMAL MODELS
Objective: To investigate the antihyperlipidemic, anti-inflammatory and analgesic properties of of E. longifolia root extract in animal models.Methods: In this study, glucose-fructose enriched diet-induced hyperlipidemia...
EXPERIMENTAL AND COMPUTATIONAL STUDY OF BINDING INTERACTION OF ALKOXY DERIVATIVES OF N-ARYLHYDROXAMIC ACIDS WITH DNA
Objective: Â Binding affinity towards DNA for small molecules is very important in the development of new therapeutic reagents. Interaction between N-Arylhydroxamic acid derivatives N-p-Tolyl-4-Ethoxybenzohydroxamic acid...
OPTIMIZATION OF NARINGINASE PRODUCTION AND ITS PURIFICATION FROM MICROCOCCUS SP.
Objective: Isolation and purification of naringinase from Mircoccus sp.Methods: The naringinase producing microorganism was isolated from the soil sample by the serial dilution method. The isolate was identified based on...
COMPARISON OF COMMERCIALLY AVAILABLE DRUGS FOR TYPE 2 DIABETES WITH NATURAL MOLECULE FROM TINOSPORA
Objective: Efficacy of natural molecule from Tinospora cordifolia versus commercially available drugs to control diabetes 2.Methods: Twelve different drug molecules were selected to study drug properties, bioactivity and...