EFFECT OF SAUDI ARABIAN Capparis Cartilaginea FRUIT EXTRACTS ON SERUM PARATHYROID HORMONE AND 1a,25-DIHYDROXYVITAMIN D3 LEVELS IN RATS
Journal Title: Journal of Experimental Biology and Agricultural Sciences - Year 2018, Vol 6, Issue 1
Abstract
Capparis cartilaginea is a shrub plant which used in traditional medicine to cure various diseases. Phytochemical analysis of Capparis cartilaginea plants extracts revealed the presence of isothiocyanates and flavonoids. A dose dependent study was designed to assess effects of Capparis cartilaginea fruit extract on serum parathyroid hormones (PTH) and 1a,25-Dihydroxyvitamin D3(1a,25(OH)2D3) levels in adult male and female Wistar rats, which could describe a regulation effect on bone metabolism. Healthy adult Wistar rats (20 female and 20 male) were treated with 1000, 2000 and 3000 mg/kg body weight (BW) of fruit extract via gavage for 6 weeks. The rats were housed under standard laboratory conditions (22±1°C and 60% humidity) for 2 weeks prior to the experiment. Blood samples were collected to determine the level of PTH and 1a,25(OH)2D3 in serum. Results of study revealed that serum PTH levels were increased in male and female rats treated with 1000, 2000 and 3000 mg/kg body Capparis cartilaginea fruit extract. The analysis of the hormones suggested a dose-dependent response in male serum PTH levels and it was significantly higher than the female PTH levels. On the other hand, all the three doses of Capparis cartilaginea fruit extract decreased 1a,25(OH)2D3 levels in both genders. The results of study indicated that Capparis cartilaginea fruit extracts have a potential to change the PTH and 1a,25(OH)2D3 hormonal levels.
Authors and Affiliations
Noor Daifallah Al-Goufi, Dr. Hala Salim Sonbol
Keywords
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