Effect of Serum Breadfruit Leaf Extract (Artocarpus Altilis) on TNF- Α and Sod Levels (Experimental Study on Guinea Pigs Exposed to UVB Light)
Journal Title: International Journal of Multidisciplinary Research and Analysis - Year 2023, Vol 6, Issue 12
Abstract
Continuous exposure to ultraviolet B (UVB) light can increase the amount of melanin, causing hyperpigmentation on the skin. This process involves the important role of Tumor Necrosis Factor-α (TNF-α) and Superoxide Dismutase (SOD). Artocarpus Altilis contain flavonoids that have anti-inflammatory potential, can reduce TNF-α levels and increase SOD which affects the melanogenesis process. To determine the effect of administering Artocarpus Altilis extract serum on TNF-α and SOD levels in guinea pigs exposed to UVB. This research is an in vivo experimental study with Post Test Only Group design, which was conducted at the IBL FK Laboratory (Integrated Biomedical Laboratory Faculty of Medicine) Unissula. A total of 30 male guinea pigs were divided into 5 groups, namely: Group 1 sham, group 2 negative control, group 3 treated with 2% Artocarpus Altilis extract serum, group 4 treated with 4% serum and group 5 treated with 6% serum. Then analyzed using the One-way ANOVA test to determine differences between groups. The lowest mean TNF-α levels were found in group P2 (4.958), other values were P1 (5.820), P3 (5.964), KS (6.069) and KN (5.811). Meanwhile, the average SOD levels in all groups were not much different, P2 (5.802), P1 (5.975), P3 (5.906), KS (6.054) and KN (6.000). In the One-way ANOVA test on TNF-α and SOD there was no significant difference, p>0.05. Administration Artocarpus Altilis extract serum, especially 4%, caused a decrease in TNF-α levels but was not significant, and there was no increase in SOD levels, in guinea pigs exposed to UVB light.
Authors and Affiliations
Nani Winarni, Pasid Harlisa, Prasetyowati Subchan
Keywords
Related Articles
- EP ID EP725745
- DOI 10.47191/ijmra/v6-i12-52
- Views 57
- Downloads 0
The Influence of Using Idol Kpop Brand Ambassador, Viral Marketing, and Lifestyle on Impulse Buying in Consumers Shopee Marketplace
This study aims to analyze the effect of using kpop idol brand ambassadors, viral marketing, and lifestyle on impulse buying on shopee marketplace consumers in Badung Regency, This research uses quantitative research met...
Pait at Paet (Pain and Chisel): The Struggles and Victories of a Santo Maker
Religious arts and crafts are culturally and spiritually relevant for many, leading to an interest for deeper understanding. The emergence of religious carving industries is essential to exploring this field. However, th...
Return on Invested Capital, Return on Investment, a Measure of the Profitability of Invested Capital, Research Evidence at Song Hong Garment Joint Stock Company
The objective of the article is to clarify investment activities, return on investment, return on invested capital, and Return on Investment's effectiveness in measuring the profitability of invested capital. To accompli...
The Counteraction of Corruption in Indonesia Based On the International Agreement (Extradition) Between Indonesia and Singapore
In early 2022, Indonesia signed an extradition agreement with Singapore. This extradition agreement with Singapore is crucial because Singapore has been one of the destinations for Indonesian fugitives, particularly in c...
Value for Money-Based Village Revenue and Expenditure Budget Performance Analysis in Katiku Tana District, Central Sumba Regency
This research uses the Value for Money measurement concept to assess the financial performance of villages in the Katiku Tana sub-district, Central Sumba Regency. The researcher used a descriptive quantitative approach w...