Effect of Short Term Administration of Diazepam and Bromazepam on Lipid Profile of Albino Wistar Rats (Rattus rattus)
Journal Title: Scholars Journal of Applied Medical Sciences - Year 2018, Vol 6, Issue 3
Abstract
Abstract: Diazepam and bromazepam though are restricted drugs are commonly used especially in this part of the world; it is a known fact that some medications has negative effect on lipid profile. The aim of this study is to investigate the effect of short term administration these drugs on albino wistar rats. This study investigated the in-vivo effect of short term administration of diazepam (DZ) and bromazepam (BZ) at 0.0046 mg/100 g bwt (1), 0.0036 mg/100 g bwt (2), 0.0026 mg/100 g bwt (3) and 0.0016 mg/100 g bwt (4) concentrations on serum lipid profile of albino wistar rats. The parameters that were investigated are: total cholesterol, triglyceride, high density lipoprotein (HDL) and low density lipoprotein (LDL). Data obtained were subjected to statistical calculation using SPSS version 18. Mean values (M) ± SD were calculated and One-Way ANOVA test was performed, significance level was calculated at 95 % confidence level (P ˂ 0.05). Serum HDL, serum LDL, serum total cholesterol, and serum triglyceride were reduced by both drugs throughout the duration of study in a dose-dependent manner. The reduction was significant (P < 0.05) for total cholesterol and triglyceride. Comparing the reducing/increasing effect between the two drugs at similar dosage showed no significant difference. Short term administration of diazepam and bromazepam at these low dosages does not affect negatively total cholesterol, triglyceride, HDL and LDL concentrations.
Authors and Affiliations
Nzor, Joyce N
Keywords
Related Articles
- EP ID EP474699
- DOI -
- Views 70
- Downloads 0
An Unusual Presentation of Gallbladder Carcinoma-Gallbladder Perforation and Anterior Abdominal Wall Abscess
Gallbladder perforation (GBP) is a rare but life threatening complication of acute cholecystitis with high morbidity and mortality rates because of delay in diagnosis. Most cases can only be diagnosed during surgery. Ni...
The Ossified Caroticoclinoid Ligament and Interclinoid Ligament in a Specimen of Sphenoid Bone: A Case Report
The interclinoid ligaments between the anterior, middle and posterior clinoid process are occasionally ossified. A bony bridge between the anterior and middle clinoid process and another between the anterior and posterio...
Oral Hygiene of Children Talibes of the Prefecture of Banamba in Mali: 205 Observations
Abstract: According to WHO, oral health is an essential and integral component of health in general. Alterations in oral health have important consequences: chewing, slurred speech, sleep and concentration, aesthetics an...
A Physiological Approach to Manage Ingrown Toe Nails
Ingrown toe nails whose synonyms are Onychocryptosis, Unguis incarnatus, and embedded toe nails are largely a disease of civilized society. The condition is rare in societies where shoe wearing is not common or who mak...
PityriasisRosea –A Comparative Histopathologic Study
Abstract: PityriasisRosea (PR) is a self-limiting dermatitis lasting from 4 to 7 weeks. PR is classified under Papulo squamous group of skin lesions which have certain common clinical presentations and lead to confusion...