Effect of Short-Term Exposure to Formalin on Male Reproductive Hormones of Students in Nnewi.
Journal Title: IOSR Journal of Dental and Medical Sciences (IOSR-JDMS) - Year 2017, Vol 16, Issue 11
Abstract
Formaldehyde is extensively used to preserve cadavers in departments of anatomy. This study investigated the effect of short-term exposure to formalin on male sex hormones levels of College of Health Sciences’ students in Nnewi, Anambra State, Nigeria. There is paucity of information on this experimental design study in Nnewi hence the research. Forty (40) apparently healthy male students aged 18-30 years, were randomly recruited into the pre and post experimental design study. Five milliliters (5mls) each of baseline and post-formalin exposure blood samples were collected from each participant and used for the analysis of biochemical parameters. Serum Testosterone, Luteinizing hormone (LH), Follicle Stimulating hormone (FSH), Estradiol (E2), and Prolactin (PRL) levels were determined using ELISA technique respectively. Data obtained were analyzed using paired Students t-test. Results showed a significant decrease in the mean serum testosterone level (11.21±5.13 vs 14.12±4.04; p=0.001) whereas, the mean serum follicle stimulating hormone (FSH) level was significantly increased (7.22±4.2 vs 6.46±4.67; p=0.025) post formalin exposure compared with pre-formalin exposure in the subjects. However, the mean serum Luteinizing hormone (LH), Estradiol, and Prolactin levels did not differ significantly after the subjects were exposed to formalin during dissection in the cadaver room when compared with their level before exposure to formalin (p>0.05). Therefore, findings in this study suggest that short term formalin exposure may predispose to hypogonadism and seminiferous tubular damage in males. Hence, adequate care is required to ensure reduction in subjects’ exposure level to this carcinogen.
Authors and Affiliations
Ihim Augustine Chinedu, Ogbodo Emmanuel Chukwuemeka, Ozuruoke Donatus Francis Ndumnworo, Amah Ubuo Kalu, Oguaka Victor Nwabunwanne, Nwovu Anthony Igube
Keywords
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- EP ID EP238773
- DOI 10.9790/0853-1611063336
- Views 137
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