Effect of Sildenafil Citrate on Fetal Color Doppler Study and Biophysical Profile in Cases of Intrauterine Growth Restriction (IUGR) in Third Trimester
Journal Title: The Egyptian Journal of Hospital Medicine - Year 2018, Vol 72, Issue 11
Abstract
<strong>Background:</strong> fetal growth restriction is an important cause of perinatal morbidity and mortality. The accurate assessment of fetal growth during pregnancy is difficult, but recent advances have improved this important aspect of obstetric care with positive implications for antenatal patients and their babies.<strong> Aim of the Work:</strong> to assess the effect of sildenafil citrate on color Doppler flow parameters in umbilical artery, Middle cerebral artery and Biophysical Profile in case of fetal growth restriction.<strong> Patients and Methods:</strong> this is a prospective cohort study of 100 pregnant females presenting for routine antenatal care at 28 + 0 weeks till delivery. A cohort of 100 pregnant females attending the antenatal care clinics at Al-Hussein university hospital and Bab El-Sharia university hospital during a period of 2 years from May 2016 to May 2018.<strong> Results:</strong> this study excluded the patients with undetermined gestational age, intrauterine infection, high risk for aneuploidy (e.g. maternal age >40 years, detected congenital fetal anomalies in the current or previous pregnancies). All cases were followed regularly twice monthly during the seventh and eighth month and then once weekly till delivery, after the administration of 20mg of sildenafil citrate every 12 hourly starting from the 28 weeks of gestation until delivery.<strong> Conclusion:</strong> the current study conclude that, administration of Sildenafil 20 mg every 12 hourly in pregnant females with fetal growth restriction (FGR) improved the feto-placental Doppler indices (pulsatility index and resistance index) of umbilical artery, middle cerebral artery.
Authors and Affiliations
Eman Helal
Keywords
Related Articles
- EP ID EP584369
- DOI 10.12816/ejhm.2018.11494
- Views 127
- Downloads 0
Evaluation of the Various Risk Factors Associated with Placenta Previa Development: A Simple Literature Review
<span>Background: </span><span>Placenta previa is defined as ,the growth of placenta in the lower uterine segment over or near </span><span>the internal cervical osseous, it’s an obstetric complication which usually occu...
uterine; artery; Doppler; solography; Pre-Eclampsia; gestation
Background: acute uncomplicated cystitis (AUC) in females is among the most frequent infections in community. Treatment of AUC in Egypt usually based on empirical therapy. Objectives: To determine the most common uropath...
Stents Technique for Endovascular Management of Intracranial Aneurysms
<strong>Background: </strong>Endovascular detachable coil embolization has become an important method in the management of intracranial aneurysms. However, coil embolization alone may fail to treat some wide-neck aneurys...
Evaluation and Comparison of Hepatic Enzymes in Different CKD Categories
Background: Chronic Kidney Disease is a global public health issue, with increasing incidence. It consists wide spectrum of renal conditions that lead to progressive decline in renal function and abnormal GFR. Liver diso...
Assessment of The Prevalence of Pelvic Floor Disorders in Both Vaginal and Cesarean Deliveries and Their Impact on The Quality of Life
Background: Pelvic floor disorders (PFDs) occurring in women comprises a broad range of clinical scenarios such as pelvic organ prolapse (POP) and stress urinary incontinence (SUI). Aim of the work: The objectives of the...