Effect of Six Weeks of Swimming Training on Malondialdehyde and Superoxide Dismutase Levels in the Heart Tissue of Mice with Breast Cancer
Journal Title: Medical Laboratory Journal - Year 2018, Vol 12, Issue 3
Abstract
Background and Objectives: Breast cancer is one of the most common cancers among women. Cardiovascular disease is one of the most important complications of breast cancer. The aim of this study was to investigate the effects of six weeks of swimming on malondialdehyde (MDA) and superoxide dismutase (SOD) levels in the heart tissue of mice with breast cancer. Method: Breast cancer was induced in 30 female Balb/c mice (6-8 weeks old, weighing 150-200 g) by tumor transplantation. The tumor site was examined every day for the formation or absence of tumor. After becoming familiar with the laboratory environment and swimming pool, the subjects were randomly divided into three equal groups: 1. healthy control, 2. cancer control, and 3. swimming-cancer. The swimming group performed swimming training 60 minutes/day, five days a week, for six weeks. After the intervention, the levels of SOD and MDA in the heart tissue samples were evaluated by enzyme-linked immunosorbent assay. Data were analyzed in SPSS (version 16) using independent t-test at significance of 0.05. Results: The results showed that induction of breast cancer was accompanied by a significant increase in MDA and a significant decrease in SOD in the heart tissue of mice. Participation in the six-week swimming significantly reversed these effects. Conclusion: Swimming could have beneficial effects in improving oxidative factors in breast cancer patients.
Isolation and Molecular Identification of Keratinase-Producing Bacteria from the Sludge of Qeshm Island
Background and Objectives: Keratinase is an enzyme commonly used in the production of detergents, cosmetics, drugs, leather, and other industries. Considering the high cost of traditional methods for decomposition of fea...
Effects of Eight Weeks of Aerobic Exercise on Markers of Oxidative Stress in Elderly Women
Background and Objectives: Oxidative stress is a common mediator in pathogenicity of established cardiovascular risk factors. The purpose of this study was to determine effects of selected aerobic training on some oxidat...
Efficacy of Mupirocin Ointment in Eradication of Staphylococcus aureus Nasal Carriage in Intensive Care Unit Staff and Patients
Background and Objectives: Staphylococcus aureus is one of the most common causes of morbidity and mortality among intensive care unit (ICU) patients. Nasal carriage is one of the main routs of S. aureus transmission bet...
Evaluation of Antibiotic Resistance Patterns and Frequency of Carbapenemase-Producing Acinetobacter baumannii Isolates by the Carbacineto NP Test
ABSTRACT Background and Objectives: Acinetobacter baumannii is an opportunistic pathogen associated with nosocomial infections. Treatment of infections caused by this bacterium has become challenging due to inc...
Effect of Six Weeks of Swimming Training on Malondialdehyde and Superoxide Dismutase Levels in the Heart Tissue of Mice with Breast Cancer
Background and Objectives: Breast cancer is one of the most common cancers among women. Cardiovascular disease is one of the most important complications of breast cancer. The aim of this study was to investigate the eff...