EFFECT OF SLEEP APNEA SYNDROME ON QT DISPERSION AND QT CORRECTED INTERVAL IN PATIENTS WITH TYPE 2 DIABETES
Journal Title: Romanian Journal of Diabetes Nutrition and Metabolic Diseases - Year 2011, Vol 18, Issue 1
Abstract
Objective. Prolonged QT interval and increased QT interval dispersion (QTd) are well-characterized precursor of malignant ventricular arrhythmias. The aim of the present study was to assess QT interval corrected for heart rate (QTc) and QTd in patients with type 2 diabetes and sleep apnea syndrome (SAS) comparative with patients with type 2 diabetes without sleep apnea. Methods. 52 subjects with type 2 diabetes were included in the study. According to apnea-hypopnea index (AHI) patients were divided into three groups: 1) control subjects (AHI < 5/hour of sleep); 2) patients with mild SAS (AHI=5-15/hour of sleep) and 3) patients with moderate–severe SAS (AHI≥15/hour of sleep). Bazett’s formula (QTc=QT/√RR) was used to obtain heart rate corrected values of the QT intervals and dispersions. Results. Prevalence of increased QTc interval in the whole population was 19.2% (10.5% in control group and 26.1% in moderate/severe SAS group). The mean QTd was 52.7 ms in all patients, with values increasing from 40.0 ms in controls to 64.8 ms in group with moderate-severe SAS. Statistically significant positive association was found between QTd and oxygen desaturation index (ODI) (β=0.38, p=0.006) and between QTd and AHI (β=0.29, p=0.03). In addition, a statistically significant negative association was found between QTd and mean SaO2 (β= -0.40, p=0.003) and between QTd and minimum SaO2 (β= -0.43, p=0.001). After adjustment for confounding factors, AHI, ODI, mean SaO2 and minimum SaO2 remained statistically significant associated with QTd. Conclusion. Sleep apnea is associated with changes in QT interval variability in patients with type 2 diabetes. Increased severity of SAS, as deter¬mined by AHI, may result in inhomogeneity of repolarization, favoring ventricular tachyarrhytmias.
Authors and Affiliations
Adriana Rusu, Cristina Nita, Cornelia Bala, Nicolae Hancu
Keywords
Related Articles
- EP ID EP124322
- DOI -
- Views 82
- Downloads 0
HIGHLIGHTS FROM THE AMERICAN DIABETES ASSOCIATION 71ST SCIENTIFIC SESSIONS
SUBCUTIS DYSTROPHY IN INSULIN TREATED CIRRHOTIC PATIENT
Insulin injections can induce local dystrophies. Many reasons can be but, the most common is the same area repeatedly injected. Our subject is a 50-year-old man insulin treated, also being under medical survey because of...
ADVANCED GLYCATION END PRODUCTS MEASURED BY AGE READER IN A GROUP OF PATIENTS WITH OBESITY
Background and Aim: Skin autofluorescence (AF) is a method used to detect the accumulation of Advanced Glycation End Products (AGEs) in skin collagen using AGE Reader. AGEs accumulation is favorised by chronic hype...
HEPATIC FIBROSIS, MEASURED BY FIBROSCANIN A GROUP OF PATIENTS WITH OBESITY
Introduction. Hepatic steatosis is a reversible condition caused by accumulation of triglycerides in liver cells. Non-alcoholic fatty liver disease (NAFLD) can progress to advanced liver disease: fibrosis, cirrhosi...
CHANGES IN PHYSICAL PROPERTIES OF SKIN IN PATIENTS WITH INSUFFICIENT THERAPEUTIC CONTROLLED DIABETES MELLITUS
Cutaneous complications are common in diabetes. Previous assays suggest that hyperglycemia and decreased insulin signal/secretion are involved in the impairment of skin function. Objective: To evaluate the biophysical ch...