EFFECT OF STABILIZERS ON THE CHEMICAL AND PHOTODEGRADATION OF ASCORBIC ACID IN AQUEOUS SOLUTION
Journal Title: Baqai Journal of Health Sciences - Year 2016, Vol 19, Issue 1
Abstract
Ascorbic acid (vitamin C) is susceptible to light and air and forms various degradation products. A number of stabilizers have been used to study their effect on the degradation of ascorbic acid (AH2) in dark and light at pH 4.0 and 6.0 alone and in combination with citric and tartaric acids. The assay of AH2 in degraded solutions was performed by a specific UV spectrometric method. The degradation product of AH2 at pH 4.0 and 6.0 was identified as dehydroascorbic acid. The degradation of AH2 has been found to follow first-order kinetics. The apparent first-order rate constants, t90 and percent inhibition in rate in the presence of stabilizers and the second-order rate constants for the interaction of stabilizers with AH2 have been determined. The highest stabilizing effect on AH2 was found by sodium metabisulfite, followed by sodium sulfite, sodium bisulfate, sodium thiosulfate and thiourea. The pH of the solutions has also been found to influence the degradation of AH2 as the rates are higher at pH 6.0 compared to those of pH 4.0, probably due to the ionization of AH2. A synergistic effect has been observed when citric or tartaric acid was added to the solutions containing stabilizers where citric acid showed comparatively better effect.
Authors and Affiliations
Iqbal Ahmad, Zufi Shad, Kiran Qadeer, Raheela Bano
Keywords
Related Articles
- EP ID EP198712
- DOI -
- Views 142
- Downloads 0
ORAL CONTROLLED RELEASE MATRIX FORMULATION DESIGN AND THEIR RATE CONTROLLING FACTORS
The trend of formulation development of controlled release (CR) matrix drug delivery system has been increased to many folds during the last few years. Such CR dosage forms are now considered to be more effective than co...
WOUND AND ITS HEALING: A CONCISE PHYSIOLOGICAL REVIEW
Wound healing is a process of the body replacing devitalized and/or missing tissue in order to fill a cavity and repair damaged skin. The process typically occurs in a coordinated manner taking up time depending upon the...
FREQUENCY OF MALARIAL PARASITE INFECTION IN HEALTHY BLOOD DONORS OF PAKISTAN
Malaria transmission through blood transfusion is although rare but clinically imperative. Certain parts of the world are at high risk of malarial infection that includes African sub-Sahara and South-East Asia. Pakistan...
IMPROVEMENT IN EDUCATION THROUGH NEUROLOGICAL PRINCIPLES
No Abstract Available
PHARMACOECONOMICAL EVALUATION OF PRESCRIBING TRENDS AND PRESCRIPTION COST ANALYSIS OF ANTI-DIABETIC DRUGS IN THE UNITED KINGDOM
This study deals with the pharmacoeconomical evaluation of the prescribing trends and prescription cost analysis of anti-diabetic drugs in UK from 1999–2015. The trend and cost estimation have been performed by the help...