EFFECT OF STREBLUS ASPER LEAVES ON LOCOMOTION, ANXIETY AND COGNITION IN RATS
Journal Title: Asian Journal of Pharamceutical and Clinical Research - Year 2019, Vol 12, Issue 2
Abstract
Objective: The current study deals with the evaluation of neuropharmacological activities of hydroalcoholic extract of the plant Streblus asper. Methods: Hydroalcoholic extract of S. asper leaves was administered to animals at the dose of 200 and 400 mg/kg p.o., respectively. The neuropharmacological activities, namely, anxiolytic, muscle-relaxant, nootropic, and locomotor activities of hydroalcoholic extract of S. asper leaves were evaluated. The antioxidant activity of the hydroalcoholic extract of S. asper leaves was also investigated. Results: The dose 400 mg/kg p.o. of hydroalcoholic extract indicated significant variation with control group on neuropharmacological activity, especially nootropic and locomotion, whereas the mentioned dose did not show a significant effect on anxiolytic and muscle-relaxant activities. Percentage scavenging activities and inhibition concentration (IC50) were reported as 63.132 at 100 μg/ml and 35.33, respectively. Conclusion: It was found that hydroalcoholic extract of S. asper leaves can treat central nervous system disorders caused by oxidative stress.
Authors and Affiliations
SACHIN NEEKHRA, HIMANI AWASTHI, DCP SINGH
Keywords
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- EP ID EP608741
- DOI 10.22159/ajpcr.2019.v12i2.28842
- Views 107
- Downloads 0
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