Effect of stress on cortisol and vanillyl mandelic acid levels
Journal Title: International Journal of Medical Science and Innovative Research (IJMSIR) - Year 2018, Vol 3, Issue 4
Abstract
Introduction and objective :Cortisol is a biochemical index of Hypothalamus-Pitutary-Adrenal (HPA) axis activation and is an important index related to psychological stress. Beside cortisol, vanillyl mandellic acid (VMA), a catecholamine is also an example of stress related biochemical index. Material and Method : On the basis of Holems & Rahe scale and HADS scale of stress, a total of 100 patients were selected for the study. Their serum cortisol was analyzed by fully automated Vidas analyzer from Biomeriuex. Urinary VMA was analyzed by kits from DRG Int using Robonik ELISA reader. Results : Mean±SD value of serum cortisol level in controls were 14.6±19.1 ng/ml and in cases 76.3±29.8 ng/ml. Mean±SD values of VMA in controls were 4.85±2.3 μg/ml of creatinine and in cases were 7.21±4.8 μg/ml of creatinine. Conclusion: Serum cortisol and urinary VMA levels were found to be significantly higher in those who were having stress (assessed on the basis of Holmes & Rahe and HADS scale) as compared to the controls.
Authors and Affiliations
Akash Gupta
Keywords
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