EFFECT OF SUBCLINICAL HYPOTHYROIDISM ON BIOCHEMICAL PARAMETERS IN PATIENTS WITH TYPE 2 DIABETES MELLITUS
Journal Title: Kocatepe Medical Journal - Year 2021, Vol 2, Issue 22
Abstract
OBJECTIVE: Subclinical hypothyroidism is a biochemical definition with elevated TSH (thyroid stimulating hormone) levels while free thyroid hormone levels are normal. Type 2 DM (diabetes mellitus) patients frequently have thyroid dysfunction, especially subclinical hypothyroidism and in these patients there are data suggesting that the increase in TSH levels leads to insulin resistance and dyslipidemia. In this study, we aimed to investigate the effect of subclinical hypothyroidism on biochemical parameters like serum lipid profile, fasting blood glucose levels and HbA1c levels in diabetic patients. MATERIAL AND METHODS: This retrospective study was conducted with 99 diabetic patients. The group that thyroid function test is coherent with subclinical hypothyroidism was named as ‘patient group’ and patients with normal thyroid function test were called ‘control group’. Patients’ demographic findings, fasting blood glucose levels, HbA1c levels, total cholesterol, LDL (low density lipoprotein), HDL (high density lipoprotein) and VLDL (very low density lipoprotein) cholesterol results were obtained from electronic files. These biochemical parameters were compared between the patient and control groups. RESULTS: The present study was conducted with a total of 99 patients, 46 (46.5%) of them are patient group and 53 (53.5%) of them are control group. Fasting blood glucose levels, HbA1c levels, total cholesterol, LDL, HDL and VLDL cholesterol, triglyceride levels were significantly higher in the patient group than the control group (p<0.05). Mean ages, free T4 levels and HDL cholesterol levels were similar between patient and control group. CONCLUSIONS: In the literature in many studies, the coexistence of type 2 DM and thyroid dysfunction has been demonstrated. The relationship between high TSH levels and high BMI (body mass index), high blood pressure, high blood insulin levels, HOMA-IR score, high blood glucose levels, HbA1c levels, total cholesterol, LDL, HDL, VLDL cholesterol and triglyceride levels were determined. In our study, similar to the literature, fasting blood glucose, HbA1c, total cholesterol, LDL, VLDL cholesterol, triglyceride levels were found to be significantly higher in the patient group than in the control group. However, comprehensive studies are needed to accurately determine the metabolic parameters affected by thyroid dysfunction in type 2 DM patients.
Authors and Affiliations
Merve HAFIZOĞLU, Memnune Sena ULU, Sinan KAZAN, Erhan BOZKURT
Keywords
Related Articles
- EP ID EP697236
- DOI https://doi.org/10.18229/kocatepetip.671434
- Views 108
- Downloads 0
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