EFFECT OF SUBMUCOSAL APROTININ INJECTION ON COMPARATIVE EVALUATION OF POSTOPERATIVE COMPLICATIONS AFTER SURGICAL REMOVAL OF MANDIBULAR 3rd MOLAR
Journal Title: Journal of Advanced Medical and Dental Sciences Research - Year 2017, Vol 5, Issue 4
Abstract
Purpose: Surgical removal of third molar is frequently associated with significant discomfort in oral health related quality of life in immediate postoperative period. There is frequent complain of pain, swelling and trismus due to acute inflammatory response to the surgical procedure. Aprotinin, an antifibrinolytic naturally occurring protease inhibitor was assessed for its efficacyin reducing post surgical complications after surgical removal of Mandibular 3rd molar. Methodology: 85 randomly selected patients who required simultaneous surgical removal of bilateral impacted mandibular third molars were included in the study. Before the procedure, randomly selected side of the patient was injected at buccal side with 1ml (10,000 IU) of aprotininsubmucosally around the surgical siteand the contra lateral side with 1ml of isotonic saline as a control. After adequate surgical anesthesia, the surgical removal of third molar was conducted in a similar manner on both sides in all the patients. Post-operatively the patients were evaluated for pain, trismus and swelling for one week (1st, 3rd and 7th day). Results: It was observed that there was noticeable clinical reduction in post-operative pain, swelling and trismus & there were no adverse effects of aprotinin. Conclusion:Current pharmacologic agents which are used , have adverse effects and associated morbidity which still pose a problem, Aprotinin, a naturally occurring agent could be efficiently used after surgical removal of third molar removal in management of post surgical symptoms and improve patient comfort and quality of life.
Authors and Affiliations
Rushik Raval, Prabhjeet Singh, Ashish Choudhary, Anjali Kundu, Manpal Kaur, Davinderjit Kaur Shergill, Jasleen Kaur
Keywords
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