EFFECT OF TARTRAZINE ORALLY ADMINISTERED ON SOME ATHEROGENIC INDICES OF ALBINO RATS
Journal Title: European Journal of Pharmaceutical and Medical Research - Year 2018, Vol 5, Issue 11
Abstract
In this study the effect of tatrazine on some atherogenic indices of albino rats were evaluated. Thirty (30) rats weighing approximately 0.14kg were used. The rats were divided into five (5) groups of six (6) rats per group. Lipid parameters such as Total Cholesterol (TC), triglyceride (TG), High Density Lipoprotein-cholesterol (HDL-C) and Low density Lipoprotein-cholesterol (LDL-C) were evaluated while atherogenic indices such as Atherogenic index of plasma (AIP), Non-high density lipoprotein cholesterol (Non-HDL-C), Atherogenic coefficient (AC), Castelli risk index 1 (CRI-1) and Castelli risk index 2 (CRI-2) were calculated as ratios of these lipid parameters. Results of atherogenic indices obtained were analysed using Graphpad Prism 5.1 with statistical significance considered at P<0.05. When atherogenic indices of tartrazine treated rats were considered, group A (control) had 0.54±0.08, 0.45±0.08, -0.09±0.08, 1.45±0.08 and 0.08±0.06 for Non HDL-C, AC, AIP, CRI-1 and CRI-11 respectively. In addition, Group B had 1.17±0.58, 0.73±0.28, -0.07±0.14, 1.72±0.28 and 0.33±0.31 for Non HDL-C, AC, AIP, CRI-1 and CRI-11 respectively while Group C had 0.74±0.26, 0.68±0.24, 0.06±0.12, 1.68±0.24 and 0.21±0.20 for Non HDL-C, AC, AIP, CRI-1 and CRI-11 respectively. More so, Group D had 0.81±0.21, 0.84±0.26, 0.09±0.06, 1.84±0.26 and 0.27±0.22 for Non HDL-C, AC, AIP, CRI-1 and CRI-11 respectively. Finally, group E had 0.81±0.10, 0.74±0.09, 0.10±0.08, 1.74±0.09 and 0.21±0.14 for Non HDL-C, AC, AIP, CRI-1 and CRI-11 respectively. The comparison of group A and B showed significant increases in Non-HDL-C, AC and CRI-1 of Group B tartrazine treated rats at p<0.05 while significant increases were observed in AC, AIP and CRI-1 when group A and C were compared at p<0.05. Also, when Group A and Group D as well as Group A and Group E were compared, significant increases were seen in Non-HDL, AC, AIP, CRI-1 and CRI-11 (table 3.5) except that the comparison between Group A and D showed non-significant increase in CRI-11 at p<0.05. The one-way analysis of variance (ANOVA) indicated significant differences in all of the indices considered except CRI-11. However, when post-analysis was done using the turkey’s comparison test, significant differences were not observed between treated groups except between Group A and Group D as well as Group A and Group E.
Authors and Affiliations
Elekima Ibioku
Keywords
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