Effect of the new plant growth regulators — n-oxide pyridine derivatives on mobile activity and energy state of infusoria tetrahymena pyriformis w
Journal Title: Український журнал сучасних проблем токсикології - Year 2018, Vol 82, Issue 2
Abstract
The study objective was to determine the functional state of infusoria Tetrahymena pyriformis W by parameters of motor activity and energy consumption for movements under acute effects of plant growth regulators — N-oxide pyridine derivatives, their complexes with organic acids and metal salts. Materials and methods. 2,6-dimethylpyridine-N-oxide, 2-methylpyridine-N-oxide and their complexes with organic acids (succinic, maleic) or metal salts (ZnCl2, ZnI2, CoCl2, MnCl2) — in total, 13 substances, synthesized at the Institute of Bioorganic Chemistry and Petrochemistry of the National Academy of Sciences of Ukraine have been used in the work. Studies have been carried out on the infusoria Tetrahymena pyriformis W in isotoxic doses — at the level of toxic concentrations — LC50, LC16 and inactive concentrations (LC0). Motor activity and energy state of infusoria using an automated laser Doppler spectrometer were evaluated. Results and conclusion. It was shown that the studied N-oxide pyridine derivatives and their complexes with organic acids or metal salts inhibit the motor activity of the infusoria and increase energy consumption for movements with the greatest effect in the concentrations of the corresponding LC50. 2,6-dimethylpyridine-N-oxide, 2-methylpyridine-N-oxide, and their complexes with succinic acid and metal salts of CoCl2 and ZnCl2 were the most toxic for the viability of infusoria. Therefore in order to assess the toxicity ofxenobiotics and viability of infusoria Tetrahymena pyriformis W, it is reasonable to recommend parameters of motor activity and energy consumption per unit of the rout that have the highest criterial significance.
Authors and Affiliations
O. P. Vasetska
Keywords
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