Effect of the polyherbal cream of Andrographis paniculata and Vernonia amygdalina in Truama wound
Journal Title: World Journal of Pharmaceutical Sciences - Year 2018, Vol 6, Issue 3
Abstract
To evaluate the wound healing benefits of Andrographis paniculata (AP) and Vernonia amygdalina (VA) as a poly-herbal cream, using shear butter as the oil phase. Excision wound was inflicted on Wistar albino rats which were divided into groups of six rats each: Group 1 received no treatment while groups 2, 3, 4, and 5 were treated with the shear butter cream base (Sbc), AP, VA, AP+VA and SSD (Silversulphadiazine) respectively. Also antibacterial activities of the extracts AP, VA and AP + VA against typed Pseudomonas aeroginosa, Staphylococcus aureus and Echerichia coli were determined. Wound healing on days 3, 6, 9 and 12 showed significant (P< 0.05) improvement in wound closure in the group treated with AP+VA as compared to the other groups. The healing of rats treated with AP+VA cream was higher than those treated with SSD when assessed in terms of wound closure, epithelization and fresh hair growth. AP+VA also showed remarkable antibacterial activity against the three screened pathogens. The study showed enhanced wound healing for the polyherbal cream: AP+VA, in comparison to AP and VA as well as SSD.
Authors and Affiliations
Builders PF
Keywords
Related Articles
- EP ID EP505705
- DOI -
- Views 91
- Downloads 0
Antiasthmatic Effect of Saxagliptin on Ovalbumin-Induced Allergic Asthma in Mice
In the current study, the protective activity of saxagliptin (SAX) on ovalbumin (OVA)-induced allergic asthma in mice was evaluated. Methods: Mice with OVA-induced allergic asthma were orally administered SAX at a dose o...
An observatory study about Diabetic Screening and Counseling OPD
Diabetes is one of the most costly and burdensome chronic diseases of contempraroy era. Individuals with type 2 diabetes are also at a significantly higher risk for coronary heart disease, peripheral vascular disease, hy...
Silver nanoparticles, Antimicrobial activity, Delonix regia, Antioxidant activity
Karpur has been used by ancient period for promotion of pain healing. A vast drug review shows that this drug also posses analgesic activity. The analgesic effect of this plant when used in anal fissure may be of great v...
Bactericidal effect of Lawsonia inermis aqueous leaf extract against selective Vibrio species of Penaeus monodon culture hatchery
The bactericidal effect of aqueous leaf extract of Lawsonia inermis against selective Vibrio species was evaluated. Vibrios are marine bacterium, responsible for disease outbreak affecting commercial production of shrimp...
Antimicrobial, Sulphorhodamine (SRB) and Antiviral Evaluation of Cyanoacrylamide Derivatives
Antitumor, antiviral, and antimicrobial evaluations were performed on a novel series of acrylamide incorporated benzo[d]thiazole compounds. The structures of these compounds were confirmed by different spectral tools. Mo...