Effect of Topical Betaxolol and Timolol on Plasma Cholesterol and Triglyceride Level in Primary Open-Angle Glaucoma of Indian Patients
Journal Title: Scholars Journal of Applied Medical Sciences - Year 2015, Vol 3, Issue 8
Abstract
Primary open angle glaucoma is the most common form of glaucoma. This type of glaucoma develops slowly and sometimes without noticeable sight loss for many years. It usually responds well to medication especially if caught early and treated. To evaluate the effect of topical timolol and betaxolol on plasma lipids particularly triglyceride and cholesterol level. Twenty patients (15 eyes ) and ten patients (12 eyes) patients of primary open-angle glaucoma with intraocular pressure (IOP) more than 26 mmHg were randomised to receive timolol maleate 0.5% and betaxolol hydrochloride 0.5%, respectively, as one drop twice a day instillation for 14 weeks. Lipid profile and IOP of each patient were recorded at 0, 6 and 14 weeks. Lipid profile was estimated in fasting condition by colorimetric method in semi automated biochemistry analyzer. In results the mean concentration of serum cholesterol(mg/dl), Triglyceride(mg/dl), HDL(mg/dl), VLDL(mg/dl) LDL(mg/dl) is 179 ±8.8 , 166.32 ±8.9 , 30.25 ±6.6 , 33.26±6.3 , 115.49±6.8 respectively in timolol treated group at the end of 14 weak as compared to 175.12 ±7.2, 146.32 ±7.4 , 33.23 ±5.4 , 33.26±6.3 , 108.63±6.8 in betaxolol treated group and the difference between them is found to be statistically significant.(p-value is less than 0.05). Topical timolol and betaxolol lowered IOP by 13.05 ± 1.53 and 16.15 ± 1.43, after 6 weeks and by 8.05 ± 1.63 and 9.12 ± 1.33mmHg respectively, after 14 weeks (p >0.05). in conclusion Topical application of betaxolol is superior and safe as compared to timolol. Keywords: Plasma lipids, topical betaxolol, timolol, glaucoma
Authors and Affiliations
Dr Rishendra Singh Sisodiya, Dr Abdulhamid S Mavli, Dr Chitrali Singh
Keywords
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