EFFECT OF TOPICAL BRIMONIDINE 0.15% VERSUS TIMOLOL 0.5% TO PREVENT INTRAOCULAR PRESSURE ELEVATION AFTER Nd-YAG LASER CAPSULOTOMY
Journal Title: Journal of Evidence Based Medicine and Healthcare - Year 2017, Vol 4, Issue 55
Abstract
BACKGROUND Posterior capsular opacification (PCO) is the most common long term complication of modern extra capsular cataract surgery techniques including phacoemulsification. The treatment of choice for clinically significant posterior capsule opacification is Neodymium: Yttrium-Aluminium-Garnet (Nd:YAG) laser posterior capsulotomy. Increased IOP is a well-known complication of Nd:YAG laser posterior capsulotomy Effective prophylaxis could prevent the possible optic nerve damage or visual field loss in susceptible patients. MATERIALS AND METHODS This prospective randomized study was conducted for one year in the Department of Ophthalmology Christian Medical College and Hospital, Ludhiana. All patients undergoing laser capsulotomy during this period were randomly distributed into two groups – A or B. Group A received 1 drop of Brimonidine 0.15%, Group B received 1 drop of 0.5% Timolol, one hour prior to presentation. Nd:YAG laser Capsulotomy was done. IOP was measured using an applanation tonometer after 1 hr, 2 hrs, 3 hrs and 4 hrs. after completion of procedure. The data was collected as per protocol and statistically analysed using t-test, Chisquare test and Z test. RESULTS There were 30 patients in each group. The baseline IOP was 15.10 ± 2.66 mmHg for group A and 16 ± 2.18 mmHg for group B (p = 0.11) (t test). There was no statistically significant reduction between the two groups in the mean IOP changes at 1, 2 or 3 hrs after Nd:YAG capsulotomy. The mean reduction in IOP after 4 hrs. for group was -1.83 mmHg and for group B was - 1.53 mmHg. The difference was statistically significant (p <0.05). CONCLUSION Brimonidine 0.15% was found to have an efficacy comparable to that of Timolol 0.5% in preventing post Nd:YAG capsulotomy IOP spikes.
Authors and Affiliations
Amruth Lal Yellamelli, Vibha Florence Baldev, Nitin Batra, Arun Bhatti
Keywords
Related Articles
- EP ID EP227469
- DOI 10.18410/jebmh/2017/668
- Views 82
- Downloads 0
CASE REPORT OF COMPOUND COMMINUTED FRACTURE CLAVICLE WITH VEIN AND PLEURAL INJURY
We report a case of compound segmental comminuted fracture of the Left clavicle, fracture of second rib, comminuted fracture of scapula with subclavian vein laceration and perforation of the parietal pleura and lung cont...
CLINICAL AND FUNCTIONAL OUTCOME OF DISTAL RADIUS FRACTURES MANAGED BY LIGAMENTOTAXIS AND/OR PERCUTANEOUS PINNING VERSUS OPEN REDUCTION & INTERNAL FIXATION BY BUTTRESS PLATES
INTRODUCTION: We studied the clinical and functional outcome of distal radius fractures managed by ligamentotaxis and/or percutaneous pinning versus open reduction & internal fixation by buttress plates. METHODS: This pr...
PERINATAL AND MATERNAL OUTCOME IN POST-DATED PREGNANCY: A RETROSPECTIVE STUDY
BACKGROUND Post-dated pregnancy is defined as one which has crossed expected date of delivery. Incidence is up to 10% of all pregnancies and carries increased risk to mother and foetus. Prolonged pregnancy has always bee...
A STUDY ON CLINICAL ANALYSIS OF PAPILLOEDEMA
BACKGROUND “Papilloedema is defined as a passive, non-inflammatory oedema of the optic nerve head due to raised intracranial pressure, which is almost always bilateral and without visual deficit”. Papilloedema is one of...
MEASUREMENT OF ENDOTRACHEAL TUBE CUFF PRESSURE IN MECHANICALLYVENTILATED PATIENTS ON ARRIVAL TO INTENSIVE CARE UNIT - A CROSS-SECTIONAL STUDY
BACKGROUND The monitoring of Endotracheal Tube (ETT) cuff pressure in intubated patients on arrival to intensive care unit is very essential. The cuff pressure must be within an optimal range of 20-30cm H2O ensuring vent...