Effect of Treatment with Aqueous Extracts of Boswellia serrata on Blood-Brain Barrier Permeability and Brain Edema in Experimental Model of Stroke in Rats
Journal Title: مجله علمی- پژوهشی دانشگاه علوم پزشکی قم - Year 2017, Vol 11, Issue 7
Abstract
Background and Objectives: Stroke is the third cause of death and disability in most human communities. Today, herbal medicines are used as alternative therapy with fewer side-effects. Frankincense (Boswellia serrata) has a rich medical history. In this study, the effect of administration of Boswellia serrata extract, was investigated on the level of blood-brain barrier (BBB) permeability and stroke-induced brain edema. Methods: In this experimental study, animals were randomly divided into 3 groups of experimental, sham, and control. The experimental group comprised 3 groups receiving aqueous extract of Boswellia serrata at doses of 50,100, and 150mg/kg bw for 30 days. The control group received distilled water, while therapy and ischemia induction, were not performed for sham group. Two hours after the last oral dose, middle cerebral artery occlusion model (MCAO) surgery was conducted on the groups to induce ischemia and assess the level of BBB permeability and brain edema. The data were analyzed using ANOVA test. Results: In this study, the Boswellia serrata (dose, 50mg/kg) had no significant effect on the BBB permeability and brain edema induced by stroke, but doses 100 and 150 mg/kg significantly reduced the permeability of BBB and brain edema compared to the control group in rats. Conclusion: According to the results of this study, pre-treatment with aqueous extract of Boswellia serrata reduces BBB permeability and brain edema in the model of ischemia-reperfusion in rats.
Authors and Affiliations
zahra zahra, Mehdi Mehdi
Keywords
Related Articles
- EP ID EP467700
- DOI -
- Views 93
- Downloads 0
Association of Adiponectin rs1501299 Gene Polymorphism with Adiponectin Levels and Type 2 Diabetes in an Iranian Population
Background and Objectives: Adiponectin is an adipokine, which is abundantly expressed in adipose tissue and has a potent roles in insulin sensitivity. This study aimed to test the association of single nucleotide polymor...
Comparison of the Immediate Effect of Contraction Maneuvers of the Abdominal Muscles on Inter-Recti Distance in Women with Diastasis Recti and Healthy Women
Background and Objectives: Diastasis recti is a common problem after delivery, which occurs due to stretch of fascia between two sides of rectus abdominis muscle. The present study was conducted with the purpose of deter...
Comparison of Alphapinene and Donpezil Effects on Passive Avoidance Memory in Adult Male Rats
Background and Objectives: Alphapinene as one of the most important Components of essential oils, which has antioxidant and anti-cholinesterase activities. Oxidative stress directly affects the function of the brain and...
بررسی فراوانی جهش 1-IVSII ژن بتاگلوبین، در بیماران مبتلا به تالاسمی مینور مراجعه‌کننده به آزمایشگاه امیرالمؤمنین (ع)، استان قم
زمینه و هدف: بتاتالاسمی، شایع‌ترین ناهنجاری آتوزومی مغلوب است. تاکنون بیش از 200 جهش شناخته شده که عملکرد ژن بتاگلوبین را تحت تأثیر قرار می‌دهد و موجب عدم تولید و یا کاهش زنجیره بتا می‌‌شود. این بیماری در ایران از شیوع...
تأثیر بیسفنول A بر ساختار بافتی کبد و آنزیم‌های کبدی
زمینه و هدف: بیسفنول A از جمله مواد شیمیایی است که به‌عنوان مونومراپوکسی رزین‌ها و پلاستیک‌های پلی‌کربنات به‌کار می‌رود. تحقیق حاضر با هدف تعیین تأثیر بیسفنولA بر میزان آنزیم‌های کبدی و ساختار بافتی کبد انجام شد. روش ب...