Effect of Trigonella, Allium Sativum and Their Mixture on Some Physiological Parameters in Hyperthyroidimic Rats
Journal Title: The Egyptian Journal of Hospital Medicine - Year 2018, Vol 71, Issue 4
Abstract
<strong>Background: </strong>alterations in the level of hormones including thyroid hormones lead to physiological/ clinical abnormalities<strong>. Aim of work:</strong> this study aimed to illustrate the protective effect of <em>Trigonella, Allium sativum</em> or their mixture against hyperthyroidism induced by L-thyroxin in male albino rats. <strong>Materials and methods: </strong> thirty albino rats were divided randomly into five groups. <strong>Group A</strong>: healthy rats, <strong>Group B: </strong>normal rats were subcutaneously injected with 500 µg/kg body weight L-thyroxin once daily for two weeks to induce hyperthyroidism, <strong>Group C</strong>: hyperthyroid rats received oral dose of 250 µg/kg body weight/day <em>Trigonella</em> extract. <strong>Group D</strong>: hyperthyroid rats received oral dose of 250 µg/kg body weight/day <em>Allium sativum</em> extract. G<strong>roup E</strong>: hyperthyroid rats received mixture of <em>Trigonella and Allium sativum</em> extract. At the end of the experiment. Blood samples were collected for biochemical analysis. <strong>Results:</strong> hyperthyroid rats had significant increase (P<0.05) in serum levels of triodothyronine (T<sub>3</sub>), thyroxin (T<sub>4</sub>), TG, VLDL, AST,ALP,BUN and uric acid as well as a significant decrease in TSH, LDL, HDL, LDL/HDL and TC, total protein and percentage of body weight change compared to the normal control group. Oral administration of these extracts ameliorated most of the tested parameters. <strong>Conclusion: </strong>This study concluded that <em>Allium sativum, Trigonella</em> or their mixture have a protective effect against hyperthyroidism <span><br /> </span>
Authors and Affiliations
Eman Helal
Keywords
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