Effect of two behavioral tests on corticosterone level in plasma of mice lacking the noradrenaline transporter.
Journal Title: Pharmacological Reports - Year 2008, Vol 60, Issue 6
Abstract
In the present study, we investigated plasma corticosterone levels of genetically modified mice lacking noradrenaline transporter (NET(-/-)), in response to the forced swim test (FST) and tail suspension test (TST). FST strongly increased the plasma corticosterone level in the first minute after the test (significantly only in NET(+/+) mice), while TST was without any significant effect in both genotypes studied. A single dose of tianeptine (20 mg/kg, ip) shortened immobility time in both tests in NET(-/-) mice, as well as NET(+/+) mice subjected to FST, but not TST. The lack of effect of tianeptine in control animals (NET(+/+)) subjected to TST is also reflected in unchanged levels of plasma corticosterone.
Authors and Affiliations
Joanna Solich, Paulina Pałach, Bogusława Budziszewska, Marta Dziedzicka-Wasylewska
Keywords
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