Effect of valproic acid monotherapy on thyroid function on short-term follow-up in children with newly diagnosed epilepsy
Journal Title: Indian Journal of Child Health - Year 2018, Vol 5, Issue 4
Abstract
Background: The effect of valproic acid (VPA) monotherapy on thyroid function test is controversial. Objective: The aim of this study is to assess the effect of VPA monotherapy on thyroid function on short-term follow-up in children with newly diagnosed epilepsy. Methods: In this prospective case–control study, conducted at the suburban tertiary care hospital in Pune, India, 55 cases of newly diagnosed epilepsy on valproate monotherapy were enrolled. 55 age- and sex-matched children were taken in the control group. Thyroid function tests were done during enrollment, at 3 months, and 6 months in case group and baseline and 6 months in the control group, and their association with serum valproate levels was correlated. Results: Thyroid functions tests were normal in all the children before the initiation of VPA therapy. On follow-up at 6 months, 12 of 55 children (21.8%) showed increasing trend of mean thyroid-stimulating hormone value which was statistically significant (p=0.003) with normal T3 and T4 levels. No statistically significant correlation was seen between serum VPA levels and thyroid function. Conclusion: Our data suggest a positive correlation between subclinical hypothyroidism and VPA monotherapy which can occur in the early course of the treatment. Therefore, it would be prudent to measure serum thyroid hormones routinely in children treated with VPA.
Authors and Affiliations
Sudhir D Malwade, Shiji S Chalipat, Kinisha Patel, Sharad R Agarkhedkar, Geeta R Karambelkar
Keywords
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