Effect of Vecuronium in different age group
Journal Title: International Archives of Integrated Medicine - Year 2016, Vol 3, Issue 9
Abstract
Background: Muscle relaxants are adjuncts to good anesthesia. Neonates and infants are having less developed neuromuscular junction, larger distribution volume and poor hepatic and renal function. The aim of the present study was to define dose of Vecuronium in neonates and infants in comparison of other age groups, to observe cardiovascular effect of Vecuronium, to study adequacy of intubating condition and, Adequacy of intra-operative muscle relaxation, To observe completeness of recovery after reversal. Materials and methods: 100% patients belonging to physical status of A.S.A Group I and II for operative procedures from both routine and emergency surgeries were selected randomly for study to observe clinical Comparison of Vecuronium bromide in different age groups. Patients were divided into 4 groups each consists of 25 Patients: Group I - Patients of 0-1 year of Age, Group II - Patients of 1-5 year of Age, Group III - Patients of 6-15 year of Age, Group IV - Patients of 16-50 year of Age. Results: Mean pulse rate before induction in Group I patient was 143.92/min., it increased to 151.92 /min. after intubation and then maintained throughout the course of anesthesia between 143.68 to 146.28 / min. which was not significant. The mean arterial pressure in Group I patient was maintained between 74.32 mm of Hg, 77.24 mm of Hg in Group II from 84.21 of pre-induction value – small changes were there and MAP maintained between 79.9 to 89.3 mm of Hg. Pre-induction MAP in Group III was 87.95 mm of Hg, it maintained between 89.29 to 92.66 mm of Hg throughout and in Group IV pre-induction value of MAP was 94.62, where it was maintained between 91.78 – 98.5 mm of Hg. So, there was no any pulse rate or blood pressure changes reflecting cardiovascular stability of Vecuronium. Conclusion: Vecuronium is an excellent non-depolarizing muscle relaxant which is an intermediate duration of action in adult but of longer duration in neonates and infants (less than 1 year). It is having advantage of – Cardiostability, Lack of Ganglion blocking action, Lack of histamine release, Non cumulative property, Excellent conditions for intubation, Excellent muscle relaxation, Complete recovery without any complication.
Authors and Affiliations
Bharti Rajani, Hitesh Brahmbhatt, Hemlata Chaudhry, Hiren Parmar
Keywords
Related Articles
- EP ID EP495469
- DOI -
- Views 115
- Downloads 0
Comparative study of hemoglobin and packed volume levels in term and preterm babies delivered in RMMCH
Background: Most existing accounts of hemoglobin values in healthy premature infants covering the early weeks of life were written before many of the errors of such determinations were recognized. Because of these limita...
Role of vertebroplasty in osteoporotic compression fracture
Majority of osteoporotic vertebral compression fracture present with back pain and some of them with spinal deformity. Percutaneous vertebroplasty not only addresses pain relief but also the correction of spinal deformit...
Comparison of various techniques in the management of fistula in ano
Introduction: Fistula in ano is the benign anorectal condition, but became a major problem for surgeons to cure the disease. For proper treatment of fistula in ano, a thorough knowledge of Anorectal anatomy and etiopatho...
Clinical outcome and response of treatment in asymptomatic bacteriuria in type I and type II diabetes in women
Back Ground: Asymptomatic bacteriuria is common in neonates, preschool children, in pregnant women, in elderly people, in diabetes mellitus, in catheterized patients and in patients with abnormal urinary tracts or renal...
Ovarian tumors - Incidence and histopathological spectrum in tertiary care center, Valsad
Introduction: Ovarian tumors are now the one of the leading cause of death involving a wide spectrum of clinical, morphological and histopathological diagnosis. It frequently does not result in symptoms until the tumor h...