Effect of Vitamin D Replacement Therapy on Glycaemic Control in Type 2 Diabetic Mellitus Patients
Journal Title: Journal of Clinical and Diagnostic Research - Year 2017, Vol 11, Issue 12
Abstract
Introduction: Vitamin deficiency has been recently shown to play an important role in the onset and progression of Type 2 Diabetes Mellitus (T2DM). The present study was planned to look for the changes in Serum 25-hydroxyvitamin D [25(OH)D] concentration and subsequent risk of type 2 diabetes levels in diabetic patients after vitamin D supplementation. Aim: To study the effect of vitamin D therapy on glycaemic control in type 2 diabetes mellitus patients. Materials and Methods: The present study was conducted in the Department of Pathology, Biochemistry and Endocrinology over a period of one year from November 2010 to December 2011. The study design was open labelled randomised controlled trial. It was a prospective study. The study was approved by the Institutional Ethics Committee and written informed consent was obtained from all the patients. Oral cholecalciferol in a dose of 60,000 units was administered every 15 days for three months to group of 30 patients selected by simple randomisation technique. Changes in fasting and postprandial sugar levels, HbA1c, routine biochemistry and total vitamin D and Parathyroid Hormone (PTH) were assessed for all patients after three months. Results: The group supplemented with vitamin D showed a significant improvement in postprandial glucose levels (p= 0.016). Fasting glucose and HbA1c values also showed a decline but it was not statistically significant. Conclusion: It is concluded that supplementation of vitamin D for three months improved levels of post prandial sugar levels in vitamin D deficient T2DM patients in the present study. Thereby raising the vitamin D levels in patients at risk of T2DM may reduce their risk or slow the development of the disease.
Authors and Affiliations
CHARU AGARWAL, SADHNA MARWAH, bindu kulshresth, Dr. Anubhuti
Keywords
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- EP ID EP367971
- DOI 10.7860/JCDR/2017/29371.11009
- Views 35
- Downloads 0
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