Effect of Vitamin D Supplementation in Patients of Moderate Asthma Undergoing Treatment with Inhaled Corticosteroids
Journal Title: Journal of Pharmaceutical Research International - Year 2017, Vol 16, Issue 4
Abstract
Background: Vitamin D is an essential nutrient with significant immunomodulatory effects. There is potential for a protective role of vitamin D against etiopathogenesis of asthma and morbidity. This study evaluated the effect of vitamin D supplementation in patients with moderate asthma. Aims and Objectives: To evaluate the effect of vitamin D supplementation on lung function improvement in patients of moderate asthma undergoing treatment with inhaled corticosteroids. Materials and Methods: An interventional prospective study. A total of 60 patients of moderate asthma were enrolled in the study and randomly divided into two groups of 30 patients each. Group A: placed on steroid based treatment regimen (formoterol 6 µg + budesonide 200 µg) + Vitamin D supplementation [60,000IU/week for 8 consecutive weeks]. Group B: placed on steroid based treatment regimen (formoterol 6 µg + budesonide 200 µg) only, as control. The enrolled patients were followed up for 12 weeks and assessed for various parameters of disease severity, asthma control and improvement in lung function by using asthma control test [ACT] questionnaire and Pulmonary function tests (spirometry). Collected data was analyzed using available statistical software [spss ver 20.0]. Results: Statistically significant changes (P<0.001) were seen in pre to post values of FEV1 [2.28±0.41 to 2.64±0.51], FVC [3.37±0.74 to 3.60±0.76] and FEV1/FVC ratio [68.44±5.03 to 73.48±3.52] in Group A as well as in Group B i.e. FEV1 [2.28±0.48 to 2.64±0.52], FVC [3.35±0.67 to 3.58±0.75] and FEV1/FVC ratio [67.87±2.48 to 74.16±4.19]. However there were no significant differences observed in pre and post values of FEV1, FVC and FEV1/FVC ratio in between the two groups. Conclusion: Vitamin D supplementation failed to show additional benefits in lung function improvement in adults with moderate asthma undergoing treatment with inhaled corticosteroids in the present study.
Authors and Affiliations
Rajendra Sharma, Sanjeev Kumar, D. C. Dhasmana, Juhi Kalra
Keywords
Related Articles
- EP ID EP312973
- DOI 10.9734/BJPR/2017/32843
- Views 119
- Downloads 0
Effects of Wild Artemisia herba-alba Essential Oil on Biofilm-Forming Bacteria
Aims: The aim of the present study was to determine the effects of essential oil of wild Artemisia herba-alba grown in south Jordan on biofilm-forming bacteria. Study Design: Seven bacterial clinical isolates were used i...
Effect of Andrographis serpyllifolia Leaves Extract on Experimentally Induced Typhoid Using Salmonella Typhi
Aims: The aim of the study was to evaluate the effect of the standardized ethanolic extract of Andrographis serpyllifolia leaves on experimentally induced typhoid. Study Design: Single dose of 1 ml Salmonella Typhi (106...
A Cross Section Study to Probe Self-prescribing Trends among the Population of Faisalabad- Pakistan
Self medication is a one of the causes of drug intoxication. The present study was planned to investigate the prevalence rate and circumstances that favor the consumer for self medication. A questionnaire was designed th...
Three Triterpenoids from the Leaf Extract of Vitex doniana (Verbenaceae)
Three triterpeniods were isolated from the leaf extract of Vitex doniana (Verbenaceae). Their structures were established mainly by FTIR, FABMS, highresolution(1Dand 2D) spectroscopic and chemical analysis as 1α, 3β-dih...
Identification of Phenolic Compounds in Hibiscus sabdariffa Polyphenolic Rich Extract (HPE) by Chromatography Techniques
The study was designed to determine the phenolic constituents of Hibiscus sabdariffa polyphenolic rich extract (HPE), (a group of phenolic compounds occurring in the dried calyx of the red variety of Hibiscus sabdariffa)...