Effect of Vitamin E Tocotrienol and Its Combination with Ascorbic Acid to Types of Leukocytes White Rat (Rattus norvegicus L.)
Journal Title: SAINS MEDIKA (Journal of Medicine and Health) - Year 2012, Vol 4, Issue 1
Abstract
ABSTRACT Background: Immunity is not separated from the role of leukocytes with various types and functions. Tocotrienol is one of the vitamin E group of compounds with antioxidant properties which to play an important role in cell repair. The aims to determine how much of the effect of vitamin E tocotrienols and its combination with ascorbic acid on the types of leukocytes. Design and Method: Preparation of blood lear dosage edge is a technique used to determine the effect of treatment between types of leukocytes. The design of experiment was conducted with three treatment that feed intake vitamin E tocotrienols and ascorbic acid and their combination with the control and 3 repetitions. Quantitative data leukocyte counts obtained by calculating the percentage of each type of leukocytes in each treatment group and the mean of the data obtained compared with normal leukocyte counts. In addition, the data is processed by the leukocyte counts of variance test using a completely randomized design (CRD) and BNT level of 5% to determine the differences between treatments. Result: The administration of vitamin E tocotrienols and its combination with ascorbic acid influenced significantly (P> 0.05) to increase the neutrophil are 31.66% and 33.66%, 24.33% and 22.33% respectively, when compared with controls. On the other hand, there is a decrease in the percentage of lymphocytes are 26.66% and 29.16%, 19.50% and 17.00% respectively, when compared with controls. Vitamin E tocotrienols and combined with ascorbic acid did not give significant effect (P <0.05) the percentage of eosinophils, basophils and monocytes. Conclusion: The administration of vitamin E tocotrienols and its combination with ascorbic acid to give effect to the increase in neutrophils (Sains Medika, 4(1):46-56).
Authors and Affiliations
Nur Auliani Lestariningrum, Ferry Fredy Karwur, Martanto Martosupono
Keywords
Related Articles
- EP ID EP234337
- DOI -
- Views 69
- Downloads 0
Students Perceptions on the quality of clinical supervision among the 12 affiliated hospital of Medical Faculty of UNISSULA
Background: Clinical supervision has a vital role in the learning process of undergraduate medical education because it may improve the student’s clinical performance of the students. Supervision is a complex activity an...
Infective Endocarditis in 60 Years Old Man at Dr. Kariadi Hospital
Infective endocarditis is an infection of the lining of the heart, particularly the cusps of valves characterized by fever and heart murmur, with or without malaise and fatigue. Clinical features can be divided into earl...
The Effect of Alium Satium Extract on the Glomerular Diameter of STZ -induced Sprague dawley Rats
Hyperglycemia exert toxic effect in kidney.The aim of this study was to investigate the short term effect of ethanolic extract of garlic in preventing nephropathy following streptozotocin (STZ) induced rats. Twenty male...
Infection Prevention Behavior of Salon Service Giver in Region Semarang Municipality
Infectious disease ranks first in the cause of morbidity in the developing countries including Indonesia especially in the eastern part of Indonesia. One of the leading infectious disease is hepatitis B that ranks ninth...
The Effects of Chronic Exposure to Airport Related Noise on Blood Pressure (A Case Study of area nearby Ahmad Yani International Airport, Semarang)
The chronic exposure of airport related noise can lead to decreased quality of health and is a risk faktor of disease. Noise can stimulate physiological response to cardiovascular parameters such as blood pressure. The i...