Effect of water-soluble gummy fiber, water-insoluble neutral detergent fiber isolated from Syzygium cumini seeds on biliary and fecal bile acids and sterols in rats fed a high
Journal Title: International Journal of Medical Science and Public Health - Year 2015, Vol 4, Issue 1
Abstract
Background: Highly viscous water-soluble fi bers present in plant materials have been shown to reduce serum levels of blood cholesterol and lipid levels in animals and human beings. The water-insoluble neutral detergent fi bers had shown no signi fi cant hypocholesterolemic and hypolipidemic effects. Objective: Effect of water-soluble gummy fi ber, water-insoluble neutral detergent fi ber isolated from Syzygium cumini seeds on biliary and fecal bile acids and sterols in rats fed a high cholesterol diet Materials andMethods: Effects of cholesterol-supplemented and cholesterol-unsupplemented diets containing 6%, 12%, and 18% water-soluble gummy fi bers and 2.25%, 5%, and 10% water-insoluble detergent fi bers were studied in both normal and diabetic rats for 21 days Results: Signi fi cant increase in biliary content and fecal excretion of bile acids was observed in rats fed for 21 days on cholesterol-supplemented and cholesterol-unsupplemented diets containing 6%, 12%, and 18% water-soluble gummy fi bers, but 2.25%, 5%, and 10% water-insoluble neutral detergent fi bers isolated from Syzygium cumini seeds had no signi fi cant effect on the above parameters. Conclusion: The increased biliary content and fecal excretion of bile acids and sterols in our study suggest that the dietary water-soluble gunny fi ber of S. cumini seeds may enhance the breakdown of cholesterol, leading to an increased conversion of cholesterol to bile acids and salts that are excreted in alimentary canal.
Authors and Affiliations
Madhuri A Agnihotri, Aqueel Khan
Keywords
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- EP ID EP106270
- DOI 10.5455/ijmsph.2015.030120148
- Views 98
- Downloads 0
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