Effect of water-soluble gummy fiber, water-insoluble neutral detergent fiber isolated from Syzygium cumini seeds on biliary and fecal bile acids and sterols in rats fed a high
Journal Title: International Journal of Medical Science and Public Health - Year 2015, Vol 4, Issue 1
Abstract
Background: Highly viscous water-soluble fi bers present in plant materials have been shown to reduce serum levels of blood cholesterol and lipid levels in animals and human beings. The water-insoluble neutral detergent fi bers had shown no signi fi cant hypocholesterolemic and hypolipidemic effects. Objective: Effect of water-soluble gummy fi ber, water-insoluble neutral detergent fi ber isolated from Syzygium cumini seeds on biliary and fecal bile acids and sterols in rats fed a high cholesterol diet Materials andMethods: Effects of cholesterol-supplemented and cholesterol-unsupplemented diets containing 6%, 12%, and 18% water-soluble gummy fi bers and 2.25%, 5%, and 10% water-insoluble detergent fi bers were studied in both normal and diabetic rats for 21 days Results: Signi fi cant increase in biliary content and fecal excretion of bile acids was observed in rats fed for 21 days on cholesterol-supplemented and cholesterol-unsupplemented diets containing 6%, 12%, and 18% water-soluble gummy fi bers, but 2.25%, 5%, and 10% water-insoluble neutral detergent fi bers isolated from Syzygium cumini seeds had no signi fi cant effect on the above parameters. Conclusion: The increased biliary content and fecal excretion of bile acids and sterols in our study suggest that the dietary water-soluble gunny fi ber of S. cumini seeds may enhance the breakdown of cholesterol, leading to an increased conversion of cholesterol to bile acids and salts that are excreted in alimentary canal.
Authors and Affiliations
Madhuri A Agnihotri, Aqueel Khan
Keywords
Related Articles
- EP ID EP106270
- DOI 10.5455/ijmsph.2015.030120148
- Views 74
- Downloads 0
Malhotra
Background: Meningitis is a common clinical problem, caused by various bacteria and viruses. Its etiology needs to be ascertained swiftly to institute appropriate therapy to prevent morbidity and mortality. In some cases...
Awareness and use of protective eye devices among auto mechanic technicians and auto spare parts traders in Uyo, Nigeria
Background: Job-related injuries are common among artisans in developing countries. In Uyo, Nigeria, data on ocular injuries at workplace are not available to guide regulatory government agencies. Objective: To de...
Microbiological profile of infection in intensive care unit and their antimicrobial susceptibility pattern with special reference to metallo β-lactamases and AmpC
Background: Throughout the world multidrug-resistant healthcare-associated infections (HAI) are one of the leading causes of morbidity and mortality among hospitalized patients, leading to a major burden on public health...
Accuracy of diagnosis of eye diseases referred by primary health-care physicians in Jeddah City, Saudi Arabia
Proper clinical approach of primary health-care (PHC) physicians is very important for proper diagnosis and management of ophthalmic diseases. Inaccurate diagnosis leads to unnecessary r...
Poor oral health as a predictor for preterm births: Do we need to revisit antenatal care guidelines for reducing preterm births? Reflections from rural Gujara
Background: Prematurity is one of the leading cause of under-5 deaths and single most important cause of neonatal mortality globally as well as in India. Still, there is a dearth of field-based research on preterm births...