Effect s of Aqueo us Ethanolic Extract of the leaves of Guiera senegalensis J.F. Gmel (C ombretacea e) on Liver Function in Wist e r Strain Albino Rats
Journal Title: International Journal of Scientific Research and Management - Year 2014, Vol 2, Issue 3
Abstract
The effects of different doses of aqueous ethanolic extract of the leaves of Guiera senegalensis on liver function test of wister strain albino rats were investigated at high doses of 1000mg/kg and 2000mg/kg which showed high toxicity with some clinical signs but at lower doses of 100mg/kg, 150mg/kg and 200mg/kg, showed little or no effects on the li ver function tests (AST, ALT, TP, ALK - PH, and ALB). Of these only ALK - PH showed significant increase (P<0.05) as the dose increases when compared with the control and total protein at only 200mg/kg. The result of these studies showed that G. Senegalensis a t lower doses is not harmful to the liver and therefore can be exploited as it is served in the treatments of some illnesses.
Authors and Affiliations
M. A. Oshobu
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