Effectiveness of Ampicillin and Ampicillin-Gentamicin for Children under Five Years Old with Pneumonia
Journal Title: Indonesian Journal of Clinical Pharmacy - Year 2018, Vol 7, Issue 1
Abstract
Pneumonia was one of the main causes of mortality in children aged under five years old. Empirical antibiotic therapy was usually selected in pneumonia because the microorganisms have not been known at diagnosis. The purpose of this study was to compare the effectiveness of empirical antibiotic therapy using ampicillin or ampicillin-gentamicin for children aged under five years old with pneumonia at one hospital in Bandung in period of 2013–2015. The method used in this study was cross-sectional method with retrospective data collection. Collected data were analyzed using Chi-Square, Fisher, and MannWhitney methods. The results showed that there was no difference in effectiveness between patients treated with ampicillin and ampicillin-gentamicin from improvement of cough (p=0.381), shortness of breath (p=0.294), fever (p=0.405), and respiratory rate (p=0.306) parameters but there was a difference in length of stay (p<0.001). Therefore, it might be the basis for the use of a single ampicillin as a primary treatment option in pneumonia for children aged under five years old. In addition, antibiotic therapy should consider other aspects such as bacterial susceptibility patterns, the risk of side effects in patients, as well as cost effectiveness.
Authors and Affiliations
Salma H. California, Rano K. Sinuraya, Eli Halimah, Anas Subarnas
Keywords
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- EP ID EP370228
- DOI 10.15416/ijcp.2018.7.1.52
- Views 80
- Downloads 0
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