Effectiveness of carbohydrate diet restriction in type 2 diabetes mellitus on insulin and incretin-based therapies
Journal Title: Asian Pacific Journal of Health Sciences - Year 2018, Vol 5, Issue 1
Abstract
Type 2 diabetes mellitus (T2DM) is the most common form of DM characterized by variable degrees of hyperglycemia, insulin resistance, and impaired insulin secretion. Insulin resistance and progressive failure of pancreatic β-cells reduce insulin secretion and consequently increase blood glucose and free fatty acid levels. The deterioration of pancreatic β-cell function in T2DM leads to therapeutic failure of oral agents over time. Hence, the most T2DM patients ultimately require insulin therapy, which may cause hypoglycemia. Regular carbohydrate intake with respect to time and amount reduces the risk for hypoglycemia in DM patients on fixed daily insulin doses. In T2DM, obesity aggravates the metabolic abnormalities such as hyperglycemia, dyslipidemia, and hypertension. Weight loss and exercise improve insulin resistance, glycemic control, and reduce risk factors in overweight and obese T2DM patients. Low caloric but healthful eating pattern promotes weight loss in overweight or obese T2DM adult patients. Incretins are released after ingestion of a meal augment the secretion of insulin and this account for the greater insulin response to oral glucose than to intravenous glucose. Incretin-based therapies along with reduced insulin doses sustain glycemic control without an increase in hypoglycemia or weight gain. The low-carbohydrate diets in T2DM patients on insulin and incretin-based therapies could increase the likelihood of hypoglycemia. Hence, as prevention of hypoglycemia is an essential part in the management of DM, the individualized dietary plan or eating pattern and adjustment of insulin and incretin doses should be considered for each patient based on his or her glycemic control.
Authors and Affiliations
Raju Panta*, Panta
Keywords
Related Articles
- EP ID EP516196
- DOI 10.21276/apjhs.2018.5.1.1
- Views 356
- Downloads 0
Knowledge attitude and practice of breast-self examination for early detectoin of breast cancer among women in roan constituency in luanshya, Copperbelt province, Zambia
Background: Breast cancer is among the commonest causes of deaths among women in the world. It is becoming a major concern for many developing countries. Early detection of breast cancer remains a vital aspect to reducin...
Study of Preanalytical errors in hematology laboratory of a tertiary care hospital
Laboratories play an important role in the diagnosis and management of the disease. Errors are part and parcel of human nature. Its human tendency to make errors. Automation in laboratories has reduced the number of erro...
Influence of Gynecologic Examination Anxiety on Application Period to Gynecology Clinics
Objective: This research was conducted as correlational descriptive study in order to determine the effect of gynecological examination anxiety experienced by women to application period of gynecology clinics.Method: Thi...
Synergistic antiulcer activity of methanolic extract of a mixture of Cinnamon cassia Bark and Annona squamosa twigs in indomethacin-induced ulcer
Background: Cinnamon cassia bark and Annona squamosa twigs have been individually described to possess antiulcer activity. In an effort to develop a pharmaceutical product with gastroprotective potential, the synergistic...
Chondrosarcoma radiotherapy with helical delivery and analysis of MR guidance
Purpose: To screen cell and metabolic qualities of chondrosarcoma of thoracic spine through the span of standard 6-week chemoradiation treatment on helical delivery with compound trade immersion exchange - MRI; and to re...