Effectiveness of ferric sodium edentate supplementation in children with lead poisoning
Journal Title: Paediatrica Indonesiana - Year 2017, Vol 57, Issue 4
Abstract
Background Lead is a harmful toxin that affects human health worldwide, especially in children. Lead poisoning remains a global problem both in developed and developing countries. The Centers for Disease Control and Prevention (CDC) recommends nutritional intervention with iron supplementation to efficiently control high lead levels. Iron supplementation in the form of sodium ferric ethylene-diaminetera-acetic acid/ ferric sodium edentate (NaFeEDTA) is highly bioavailable.Objective To determine the effectiveness of ferric sodium edentate (NaFeEDTA) on lead levels in children woaj ;ead [pospmomg.Methods This interventional, analytical study, had a one group pretest-posttest design, and was done on children in four elementary schools in the Talawaan District, North Minahasa Regency from August to November 2014. Inclusion criteria were elementary students aged 6-9 years with lead poisoning (lead levels ≥ 10 μg/dL) and good nutritional status. Subjects were given NaFeEDTA 115.4 mg (15 mg elemental iron) at a dosage of 3 mg/kgBW/day elemental iron given between meal times. Iron supplementation was given daily per oral route for 12 weeks. Descriptive analysis was used to analyze the characteristics of the study sample. Pre- and post-test analyses were done with paired T-tests. Significance level was P <0.05.Results In this study, 39 children met the inclusion criteria and consisted of 19 boys and 20 girls. Their mean age was 8.43 (SD 0.44) years. Pre-test and post-test blood lead levels was 36.18 μg/dL and 5.22 μg/dL, respectively.There was a significant reduction in mean blood lead levels after administration of NaFeEDTA (P <0.0001).Conclusion In children with lead poisoning, blood lead levels are significantly reduced after 12 weeks of NaFeEDTA supplementation.
Authors and Affiliations
Praevilia Salendu, Nurhayati Masloman, Sarah Warouw
PELOD score, serum procalcitonin, and lactate levels in pediatric sepsis
Background Sepsis remains a major cause of morbidity and mortality among critically ill children in the pediatric intensive care unit (PICU). Procalcitonin and lactate have been used as biomarkers of sepsis, as they have...
Gut wall integrity in exclusively breastfed vs. formula-fed infants
Background Breast milk has bioactive substances that modulate gastrointestinal maturation and maintain mucosal integrity of the gut in infants. Markers that are both non-invasive and reliable, such as fecal alpha-1 antit...
Prevalence and risk factors of hearing loss in children with solid tumors treated with platinum-based chemotherapy
Background The platinum-based chemotherapy drugs, cisplatin and carboplatin, are widely used in the treatment of several types of solid tumors. However, the treatment has side effects including hearing loss.Objective To...
Selenium for acute watery diarrhea in children
Background Acute watery diarrhea remains a major health problem affecting infants and children in developing countries. Selenium deficiency may be a risk factor for diarrhea and vice versa. Few studies have been conducte...
Physical activity assessments in obese and non-obese adolescents using the Bouchard diary
Background Obesity is now a global epidemic problem. Increasedprevalence of obesity is associated with increased sedentarybeh avior and low physical activity.Objective To assess the physical activity patterns of adolesce...