Effectiveness of ferric sodium edentate supplementation in children with lead poisoning
Journal Title: Paediatrica Indonesiana - Year 2017, Vol 57, Issue 4
Abstract
Background Lead is a harmful toxin that affects human health worldwide, especially in children. Lead poisoning remains a global problem both in developed and developing countries. The Centers for Disease Control and Prevention (CDC) recommends nutritional intervention with iron supplementation to efficiently control high lead levels. Iron supplementation in the form of sodium ferric ethylene-diaminetera-acetic acid/ ferric sodium edentate (NaFeEDTA) is highly bioavailable.Objective To determine the effectiveness of ferric sodium edentate (NaFeEDTA) on lead levels in children woaj ;ead [pospmomg.Methods This interventional, analytical study, had a one group pretest-posttest design, and was done on children in four elementary schools in the Talawaan District, North Minahasa Regency from August to November 2014. Inclusion criteria were elementary students aged 6-9 years with lead poisoning (lead levels ≥ 10 μg/dL) and good nutritional status. Subjects were given NaFeEDTA 115.4 mg (15 mg elemental iron) at a dosage of 3 mg/kgBW/day elemental iron given between meal times. Iron supplementation was given daily per oral route for 12 weeks. Descriptive analysis was used to analyze the characteristics of the study sample. Pre- and post-test analyses were done with paired T-tests. Significance level was P <0.05.Results In this study, 39 children met the inclusion criteria and consisted of 19 boys and 20 girls. Their mean age was 8.43 (SD 0.44) years. Pre-test and post-test blood lead levels was 36.18 μg/dL and 5.22 μg/dL, respectively.There was a significant reduction in mean blood lead levels after administration of NaFeEDTA (P <0.0001).Conclusion In children with lead poisoning, blood lead levels are significantly reduced after 12 weeks of NaFeEDTA supplementation.
Authors and Affiliations
Praevilia Salendu, Nurhayati Masloman, Sarah Warouw
Keywords
Related Articles
- EP ID EP438252
- DOI 10.14238/pi57.4.2017.171-5
- Views 40
- Downloads 0
Superoxide dismutase levels and peak expiratory flow in asthmatic children
Background Asthma is a chronic inflammatory process which involve variety of cells such as inflammatory mediators, reactive oxygen species (ROS), and cytokines. The inflammatory process would be exacerbated in the presen...
Short term memory, physical fitness, and serum brain-derived neurotrophic factor in obese adolescents
Background Obesity in adolescents is a major health problem and has been associated with low academic achievement. Brainderived neurotrophic factor (BDNF), a neurotrophin, plays a role in appetite suppression and memory,...
Irrational use of antibiotics and clinical outcomes in children with pneumonia
Background Pneumonia is a major cause of morbidity and mortality in children under five. Antibiotic treatment must be started immediately in children with pneumonia. The irrational use of antibiotics may increase morbidi...
Social competence of 3 to 5-year-old children born with low birth weight
Background Low birth weight (LBW) has long been used as an indicator of public health. Low birth weight is not a proxy for any dimension of other maternal or perinatal health outcomes. Low birth weight infants require sp...
Correlation between lipid profile and C-reactive protein in children with nephrotic syndrome
Background Nephrotic syndrome (NS) causes dyslipidemia in children, which can be long term or intermittent. Dyslipidemia has long been established as a risk factor for atherosclerosis. An early sign of atherosclerosis is...