Effectiveness of Intralesional Bleomycin Sclerotherapy for Lymphangioma in Children
Journal Title: Journal of Medical Science And clinical Research - Year 2018, Vol 6, Issue 1
Abstract
Introduction: Lymphangiomas are congenital lymphatic malformations. The treatment of choice is surgical excision, but it has a high rate of complications and recurrences. Many investigators have assessed numerous alternative approaches. Local injection of bleomycin has been found to be an efficacious therapy without opting for surgery. This study assesses the effectiveness of Intralesional Bleomycin Sclerotherapy (IBS) in treating children for lymphangiomas, primarily in terms of reduction in size. Methods: This prospective interventional study was conducted at the Pediatric Surgery Department, Children Hospital PIMS, Islamabad, from July 1st, 2013 to March 31st, 2014. Sixty children with cystic hygroma were included in this study. Bleomycin aqueous solution was injected into the lesion postaspiration, and patients were hospitalized for 24 hours post-procedure. The final assessment was made after 3 months post-injection sclerotherapy with Bleomycin to see the effect on the size of the lesion. Results: The average age of the studied patients was 35.325.4 months. There were 23 (38.3%) males and 37 (61.7%) females. The most frequent site was the neck in 38 (63.3%) children, other sites included face 8 (13.3%), axilla 8 (13.3%), and trunk 6 (10%). A single injection was effective in 3 (5%) patients, two injections were required in 21 (35%) and three injections were given in 36 (60%). Forty-three (71.7%) patients showed an excellent response, 12 (20%) patients showed a good response, and 5 (8.3%) showed a poor response to intralesional Bleomycin sclerotherapy. Conclusion: Intralesional injection of bleomycin in children with lymphangioma is an effective method of achieving excellent to good results in more than 90% patients over three months.
Authors and Affiliations
Dr Adnan Bashir Bhatti, MD
Keywords
Related Articles
- EP ID EP538701
- DOI -
- Views 92
- Downloads 0
Factors Associated with the Use of Endoskeletal and Exoskeletal Prosthesis Among Lower Extremity Amputees - A Tertiary Care Centre Experience
Background: Prostheses are used after amputation for better function, cosmetic appearance, and a psycho-spiritual sense of wellbeing. But they are mired by discomforts and disadvantages. Compared to the conventional exos...
A Rare Case of 12 Year Old Girl with Giant Fibroadenoma with Phylloides Tumour showing Features of Intraductal Papilloma
Breast tumours in prepubertal females are usually rare. Most commonly they present as adult type Fibroadenoma (FA).We reporta rare case of 12 year old girl who presented to our side with a painless progressive breast lum...
Serum Lymphocyte Activating Factor of Tumor Necrosis Super family (BAFF) and a Proliferation Inducing Ligand (April): Correlation with Activity and Chronicity Indices in Egyptian Adolescent Lupus Patients with and Without Nephritis
Dysfunction of the B lymphocyte is considered to be involved in the pathogenesis of lupus nephritis (LN) intrarenal B cells have been found in several forms of inflammatory kidney disease. B lymphocyte stimulator signali...
Malignant Peripheral Nerve Sheath Tumor: A Rare Case and Review of Literature
Malignant peripheral nerve sheath tumors are a rare type of cancer that arise from the soft tissue that surrounds nerves. They are a type of sarcoma. Most malignant peripheral nerve sheath tumors arise from the nerve ple...
Study for Comparison of Iron Sucrose & Iron Sorbitol Citrate in Fixed Doses in Iron Deficiency Anemia during Pregnancy in a Tertiary Care Center
Background: Anemia is one of the most commonly encountered medical disorders in pregnancy & Iron deficiency is the leading cause of anemia in pregnancy. Aim of the study was to assess the efficacy of Iron Sucrose and Iro...