Effectiveness of I.V Clonidine Hydrochloride And I.V Esmolol Hydrochloride In Attenuation of Cardiovascular Responses To Laryngoscopy And Endotracheal Intubation
Journal Title: International Journal of Medical Science and Innovative Research (IJMSIR) - Year 2018, Vol 3, Issue 1
Abstract
Aim & Objective : The occurrence of haemodynamic response during laryngoscopy and endotracheal intubation is a well-known hazard as the increase in heart rate, blood pressure is usually transitory, variable and unpredictable. In view of these changes the objective of our study was to compare I.V esmolol and I.V clonidine in attenuation of haemodynamic response to laryngoscopy and endotracheal intubation by changes in heart rate, systolic blood pressure, diastolic blood pressure, mean arterial pressure. Method: Our study was clinical prospective, randomized, interventional study including 90 Indian Ethicinicity patient of either gender requiring oral endotracheal intubation who met the inclusion criteria, were considered. The patients were randomly stratified in three groups (n=30 each) Group I (clonidine 1mcg/kg), Group II (Esmolol 1.5mg/kg), Group III(Control) 10mins, 3mins before laryngoscopy and intubation. Data obtained was analysed by Analysis of variance (ANOVA), unpaired T test and chi square test to find the significance of parameters on categorical scale between the three groups. Results: In our study there was a maximum rise in mean heart rate, meanSBP, meanDBP, meanMAP was at the time of laryngoscopy and intubation in all 3 groups. The rise was minimum in Esmolol group as compared to Clonidine group and Control group. From 1st min onwards there was a gradual fall in mean heart rate, meanSBP, meanDBP, meanMAP at all the time intervals. The mean heart rate, meanSBP, meanDBP, meanMAP in Esmolol group reached near baseline at 3rd min. In Clonidine group at 7th min the mean heart rate and at 5th min the meanSBP, meanDBP, meanMAP reach near baseline. The mean heart rate, meanSBP, meanDBP, meanMAP was significantly high at all the intervals in Control group and did not reach baseline. Conclusion: Esmolol Hydrochloride 1.5mg/kg i.v was better as compared to Clonidine hydrochloride 1mcg/kg i.v in attenuation of haemodynamic response to laryngoscopy and endotracheal intubation.
Authors and Affiliations
Dr. Amruta . A. Mankar
Keywords
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