EFFECTIVENESS OF MADHUCA LONGIFOLIA ROOT BARK POWDER FOR WOUND HEALING ACTIVITY IN WISTAR ALBINO RATS.
Journal Title: European Journal of Biomedical and Pharmaceutical Sciences - Year 2018, Vol 5, Issue 1
Abstract
Wound healing is the process of repair that follows injury to the skin and other soft tissues. Following injury, an inflammatory response occurs and the cells below the dermis deepest begin to increase collagen production. Later, the epithelial tissue is regenerated. There are three stages to the process of wound healing: inflammation, proliferation, and remodeling. Traditionally, Madhuca longifolia is used for wound healing. Since no detailed scientific data are available regarding the wound-healing activity of Madhuca longifolia, the present study was designed to explore the same. The aim of this study is to identify the effectiveness of Madhuca longifolia root bark powder in wound healing activity on animal model. It is an experimental study on healthy wistar albino rats. It was evaluated in excision wound model. The animals were distributed into 3 groups of 3 each. The animals of group A were left untreated and considered as control. Group B served as standard and received cloxacillin. Group C was considered as test and treated with prepared test drug. Powder of test drug and standard drug were topically applied 500mg every alternative day and bandaged starting from the day of operation, till complete epithelialization up to 14 days. The direct observation of wound size, Exudates type and amount, edges, necrotic tissue type and skin coloration of surrounding wound were records converted into Bates-Jensen Wound assessment Tool. Control group showed continuing recovery due to physiological healing during the experiment up to 14 days. The Test and Standard groups showed considerably minimum duration for complete wound healing. The time duration for complete wound healing of the standard drug was observed 14 days where as Test drug, it was only 12 days. Madhuca longifolia root bark powder showed as 60.78% of effectiveness while the standards effectiveness 58.82%. It shows that Test drug is more effectiveness than Standard drug. So it is clearly denotes powder of Madhuca longifolia root bark is effective on wound healing.
Authors and Affiliations
Dr. Piratheepkumar R.
Keywords
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