Effectiveness of nestroft as a screening test for the detection of β-thalassemia trait
Journal Title: Scientific Journal of Medical Science - Year 2014, Vol 3, Issue 4
Abstract
The present study was carried out to evaluate the effectiveness of NESTROFT as a screening test for β-thalassemia trait. Naked Eye Single Tube Red cell Osmotic Fragility Test [NESTROFT] is an un-cumbersome and inexpensive test for the detection of β-thalassemia. NESTROFT was applied to 150 patients of β-thalassemia trait and 150 normal control samples. The test was successful in detecting 143 subjects with β thalassemia trait, and negative in all 150 control samples. Sensitivity of the test was 95.2% and specificity was 62.6%. Positive predictive value of NESTROFT was 60.5% and Negative predictive value of NESTROFT was 89.0%. NESTROFT is suitable for screening the suspected cases of β-thalassemia trait as it is easy to perform, can be used for field studies, inexpensive and does not require any sophisticated equipments. NESTORFT is found to be singly most cost effective and promising screening test to detect thalassemia heterozygotes.
Authors and Affiliations
S. B. Satpute| Assistant Professor, Department of Biochemistry, Govt. Medical College, Miraj., M. P. Bankar| Professor, B. J. Government Medical College, Pune., A. Momin| Assistant Professor, Department of Biochemistry, IMSR, Mayani, Satara., G. M. Bhoite| Assistant Professor, Department of Human Physiology & Biochemistry, BVDU Dental College, Pune.
Keywords
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- EP ID EP1267
- DOI 10.14196/sjms.v3.i4.1228
- Views 497
- Downloads 30
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