Effectiveness of Triple Therapy Regimens in the Eradication of Helicobacter pylori in Patients with Uninvestigated Dyspepsia in Ekiti State, Nigeria
Journal Title: Journal of Advances in Medicine and Medical Research - Year 2015, Vol 6, Issue 3
Abstract
Aim and Objective: The term dyspepsia has been used inconsistently by healthcare professionals to describe different patterns of upper gastrointestinal symptoms. It denotes a symptom and does not itself represent a disease. In this study, we seek to determine the effectiveness of common triple therapy regimens in use in the eradication of H. pylori in this environment and to compare it what is obtained worldwide. Materials and Methods: One hundred and four Consecutive adult patients, aged 18 to 50 years presenting newly with uninvestigated dyspepsia and without alarm symptoms at General Outpatient Clinics of the Ekiti State University Teaching Hospital, Ado-Ekiti and the Federal Medical Centre, Ido-Ekiti, Nigeria were randomized into five treatment groups in the study. Approval was obtained from Ethical Committees of the two study centres. Treatment outcome was computed using frequency table. Results: The mean age of the studied population was 37.8±12.98 years. 32.7% were males while 67.3% were females. Most prevalent symptom for uninvestigated dyspepsia was abdominal discomfort 100 (96.2%), this was followed by early satiety, abdominal fullness and vomiting with 32 (30.8%), 26 (25%) and 13 (12.5%) of the participants respectively. 76.0% were positive for H. pylori infection by Urea Breath Test Heliprobe® System with highest prevalence of H. Pylori infection within age group 31-45 years (36.7%). Rabeprazole-Clarithromycin-Metronidazole group (RCM) had the highest eradication rate per protocol [77.8%], followed in descending order by Rabeprazole-Amoxil- Levofloxacin group (RAL) [53.3%], Omeprazole-Tinidazole-Clarithromycin “ulcer kit” (OTC) [44.4%], Rabeprazole-Amoxil-Metronidazole group (RAM) [44.4%] and Rabeprazole-Amoxil-Clarithromycin (RAC) [30.0%]. Conclusion: This study showed there is difference in eradication rates of popularly known triple therapy regimens. This may be due to geographical differences in antibiotics resistant pattern to H. pylori. Further study is suggested to find out the national sensitivity pattern to the commonly used triple therapy regimens in Nigeria.
Authors and Affiliations
Olusoji A. Solomon, Akande O. Ajayi, Patrick T. Adegun, Olusegun E. Gabriel, Ohunakin Afolabi, Oluremi O. Solomon
Keywords
Related Articles
- EP ID EP347427
- DOI 10.9734/BJMMR/2015/14103
- Views 80
- Downloads 0
Sulfasalazine Induced DRESS Syndrome: A Review of Case Reports
Introduction: Drug Rash with Eosinophilia and Systemic Symptoms (DRESS) is designated as a lethal adverse drug effect with characteristic sign and symptoms such as skin rashes, fever, leukocytosis with eosinophilia or at...
Peripheral Cemento-ossifying Fibroma -treatment and Follow Up of a Recurrent Case
Peripheral cemento-ossifying fibroma is a non neoplastic growth of soft tissue which often arises from the interdental papilla and is mostly seen in teenagers and young adults. Here we discuss a case of peripheral ceme...
Knowledge, Attitudes and Perception of the Hospital Staff towards Smoking at Sahloul Hospital - Sousse- Tunisia
Background: In Tunisia, smoking remains prevalent among the health professionals. In order to combat this epidemic, it is necessary to start a tobacco control strategy. Objectives: Our work aims to study the knowledge a...
Primary Small B-cell Lymphoma (MALT Lymphoma) at Lingual Tonsil: A Case Report
Aims: Primary non-Hodgkin’s lymphomas of the oropharyngeal region are rare. We report a case of a small B-cell lymphoma (MALT lymphoma) involving base of tongue. The patient was successfully treated with wide excision of...
Stability and Effects of Mandibular Symphyseal Distraction Osteogenesis: A Systematic Review
Aims: Expanding mandibular arch for correcting transverse deficiency is a challenging problem in orthodontics. It is believed that mandibular symphyseal distraction osteogenesis (MSDO) is an attractive solution for this...