EFFECTIVENESS OF TWO PHYSICAL ACTIVITY PROGRAMS ON NON-ALCOHOLIC FATTY LIVER DISEASE. A RANDOMIZED CONTROLLED CLINICAL TRIAL.
Journal Title: INTERNATIONAL JOURNAL OF PURE MEDICAL RESEARCH - Year 2018, Vol 3, Issue 8
Abstract
BACKGROUND & AIMS: Several studies have shown that lifestyle modication (reduced energy intake and/or increased physical activity) reduces Non-Alcoholic Fatty Liver Disease (NAFLD). We hypothesized that Aerobic exercise is more efficient to reduce NAFLD score in a primary care setting. Primary aim of this study was to estimate the effectiveness of two physical activity programs on NAFLD METHODS: Participants come from a survey conducted in the Apulian region of Italy. Subject with moderate or severe NAFLD were invited to participate. After informed consent, they completed a questionnaire, underwent ultrasonography and anthropometric measurements. Thus, they were randomized: Aerobic or Combined Exercise programs and followed-up for six months. Adherence to the intervention was measured. A mixed linear model was applied to the data. RESULTS: Adherence to Aerobic Exercise was homogeneous and increased with time. Combined Program adherence was equal to 100% in every month for all subjects. There was no signicant difference in NAFLD mean score by treatment at baseline (p=0.22) and after six months (p=0.65). However, there was a signicant reduction in NAFLD mean score for treatments after six months (p< 0.01). The NAFLD measured score was reduced, on average, 22% in the Aerobic treatment group. CONCLUSIONS: Combined program after 6 months was less or not as effective as Aerobic Exercise in reducing NAFLD score. This nding is relevant as Aerobic exercise programs are simple to implement and the cost-effectiveness is higher. Moreover, Aerobic exercise program is a realistic intervention which could be part of primary prevention of several chronic diseases.
Authors and Affiliations
Isabella Franco, Antonella Bianco, María del Pilar Díaz, Caterina Bon, Marisa Chiloiro, Sonia A Pou, Julia Becaria Coquet, Alessandro Nitti, Angelo Campanella, Maria G Caruso, Mario Correale, Alberto R Osella
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