Effectiveness, safety and cost analysis of add-on pidotimod in maintenance therapy for exacerbation of chronic obstructive pulmonary disease in adults
Journal Title: IP Indian Journal of Immunology and Respiratory Medicine - Year 2018, Vol 3, Issue 4
Abstract
Acute exacerbation of chronic obstructive pulmonary disease AECOPD is the sudden worsening in airway function and respiratory symptoms in patients with COPD which range from selflimited diseases to episodes of florid respiratory failure requiring mechanical ventilation An average patient with COPD might experience 2 episodes of AECOPD per year and 10 of these episodes require hospitalization Pidotimod an immunostimulant has shown promising results in conditions with underlying cause of suppressed cellmediated immunity like chronic bronchitis and recurrent respiratory tract infection RRTI The current study evaluated the safety efficacy and cost effectiveness of Pidotimod in adult Indian patients with COPD as an addon drug in maintenance therapy of acute exacerbations In this prospective open label single arm single centre study Pidotimod was administered as an addon therapy for 2 months in 114 patients 18 years and 55years mean age 5951 866 years with COPD having experienced two or more exacerbation that required antibiotics The study comprised of screening visit enrolment and 3 followup visits at the end of 2 6 and 12 months Of the 111 patients at baseline only one patient had an AECB episode at 2 and 6 months At the end of 12 months none of the patient had an AECB Only one subject was prescribed with antibiotic treatment at the end of 2 and 6 months No episodes of either exacerbations or antibiotic prescription at the end of 12 months were reported A significant reduction pKeywords Immunostimulant Pidotimod Acute exacerbations of chronic bronchitis AECB Costanalysis Respiratory infections
Authors and Affiliations
Ashish Goyal
Keywords
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- EP ID EP490623
- DOI 10.18231/2581-4222.2018.0049
- Views 61
- Downloads 0
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