Effectivity comparison of amitriptyline versus gabapentin as neurophatic pain therapy in elderly with type ii diabetes mellitus
Journal Title: INTERNATIONAL JOURNAL OF CURRENT RESEARCH - Year 2017, Vol 9, Issue 1
Abstract
Background: Neuropathy in diabetes mellitus is a disorder that occurs in the peripheral nervous system. The incidence of diabetic neuropathy was found more prevalent in elderly (44%) compared to adult (24%). Amitriptyline and Gabapentin are widely used on treatment of neuropathic pain. There were variations in the results of the studies that have been done related to effectiveness between both drugs, causes the need further research, especially on geriatrics. Objective: The aim of this study was to compare the effectiveness of Amitriptyline versus Gabapentin for diabetic neuropathic pain in geriatric. Methods: A prospective cohort study involving 70 elderly were observed during 4 weeks. The outcome targets were neuropathy pain scale reduction (≥ 2 unit). Non-parametric Wilcoxon, Mann Whitney U, and Chi-Square test were used to analyze the outcome. Result: The whole subjects who got Amitriptyline or Gabapentin decreased pain scale ≥ 2 units compared to baseline. Comparison head to head at low doses, Amitriptyline showed reduce pain intensity greater than Gabapentin (p < 0.05), while on therapeutic doses show there was no difference in efficacy between two drugs (p > 0.05). Conclusion: Amitriptyline was found better in reducing diabetic neuropathic pain intensity compared to Gabapentin.
Authors and Affiliations
Made Krisna Adi, Fauna Herawati
Keywords
Related Articles
- EP ID EP399638
- DOI -
- Views 145
- Downloads 0
A comparative study of factors influencing guidance and counselling help-seeking behaviour among public secondary school students in nyeri And nairobi counties, kenya
Secondary school students are exposed to social, educational, vocational and psychological problems which they are unable to handle on their own. However, many students, instead of seeking counselling when they have prob...
Comparison of staining of mitotic figures by h and e and crystal violet stains in odontogenic tumors with aggressive behaviour- a preliminary study
Background: Some odontogenic tumors are clinically benign but they are locally aggressive and recur. Therefore such lesions should be completely evaluated for their mitotic potential. Routine staining procedures often po...
Negative effects of sports on oral health: a systematic review
Background: The aim of this study is to systematically review the impact of sports on oral health. Objective: Understanding the physiological effects of sports on the oral health. Methods: A review of previous literature...
Lifestyles of the elderly in the city of san francisco de campeche
The three major factors that affect health and that must be taken into account for a comprehensive action on lifestyles are: individual, social and environmental factors. These factors could be developed exhaustively, bu...
About cases of occupational allergies detected in workers followed by the service of medicine of work of chu tlemcen
Allergic manifestations in the workplace, including allergic contact dermatitis, are increasingly common. In addition, the association between skin and respiratory allergy is little reported in the literature. We study t...