EFFECTIVNESS OF GLUTATHIONE (GSH) 2%, TOCOPHERYL ACETATE 1%, AND MAGNESIUM ASCORBYL PHOSPHATE 3% COMBINATION CREAM COMPARED WITH HYDROQUINONE 4% CREAM AS A SKIN LIGHTENING AGENT: A RANDOMISED STUDY
Journal Title: International Journal of Medical Reviews and Case Reports - Year 2018, Vol 2, Issue 4
Abstract
Black spots and brown spots interfere with aesthetic appearance. For this reason, there are various skin lightening products on the market, such as glutathione, vitamin C, and E. The combination of glutathione, vitamin C, and E, which is a natural antioxidant, is expected to have an equivalent effect with hydroquinone (standard therapy), but with minimal side effects. The aim of this study was to determine the score of skin brightness using Chroma Meter on the subjects before the topical glutathione (GSH) 2%, 1% tocopheryl acetate 1%, and 3% magnesium ascorbyl phosphate 3% combination therapy compared with hydroquinone 4% cream after 6 weeks of administration. A double-blind, pre- and post-treatment randomized controlled clinical trial was conducted on 34 patients at the Dermatology and Venereology clinic of Hasanuddin University Hospital in Makassar, by applying combination cream and hydroquinone on the patient's right arm twice daily. Measurement of skin brightness and erythema using Chroma Meter performed weekly. The results of the study using Wilcoxon Signed Rank and Mann-Whitney test found that the L* (brightness) score in combination cream group was significantly higher than in the hydroquinone cream group (p <0.001). As for the a* (erythema), the score of a* (erythema) in the hydroquinone cream group was significantly higher than in the combination cream group (p <0.001). Measurement of ITA0 score (Individual Typological Angle) after 6 weeks was obtained, and showed that the score in combination cream group was significantly higher than in hydroquinone cream group (p <0.001). Combination cream showed a higher score in terms of brightening the skin than with hydroquinone cream, whereas the score of skin erythema increased significantly with the use of hydroquinone cream compared to the combination cream for 6 weeks. It is hoped that subsequent research could be done with a larger sample and longer time to get more representative results of the population.
Authors and Affiliations
Andy Manggabarani, Farida Tabri, Anis Irawan, Arifin Seweng, Agussalim Bukhari, Khairuddin Djawad
EFFECT OF CURCUMA LONGA 0.5% EXTRACT ON SEBUM COMPOSITION AND SKIN MOISTURE IN DRY SKIN PATIENTS
Introduction Dry skin is a problem for millions of people and often causes discomfort and even psychological stress. Curcuma Longa (C. Longa) has been known to have an effect in improving skin texture due to exogenous ef...
Cost economics of endovascular coiling versus surgical clipping of intracranial aneurysm: Literature review and critical analysis
Background Cost-effectiveness of medical intervention is becoming increasingly important in healthcare delivery, treatment in Neurosurgery is very expensive and there have been very few publications on neurosurgical heal...
Doctors of debt: Cutting or capping the Public Service Loan Forgiveness Program (PSLF) hurts physicians in training
Growing medical student debt has increased reliance on government loan forgiveness plans like the Public Service Loan Forgiveness Program (PSLF). Evidence suggests that delayed financial gratification in addition to stag...
An original reconstruction of a full thickness defect secondary to a parietal invading bladder tumor
Backgrounds: The reconstruction of large full-thickness abdominal wall defects usually requires microsurgical flaps. When microsurgery is not an option, the association of two pedicled flaps can be an alternative. This a...
SUCCESSFUL MANAGEMENT OF RADIAL NERVE PARALYSIS IN A 2 YEAR-OLD MONGREL
A 2 year-old mongrel was presented to the Veterinary teaching hospital, University of Ibadan with knuckling of the right forelimb. The client gave history of automobile accident. The animal was clinically evaluated with...