EFFECTS OF A. MELLIFICA EXTRACT ON THE HEMATOLOGICAL, BIOCHEMICAL, URINE AND HISTO-PATHOLOGICAL PARAMETERS OF WHITE ALBINO RABBITS
Journal Title: International Journal of Pharmacy and Pharmaceutical Sciences - Year 2015, Vol 7, Issue 5
Abstract
Objective: To observe the effects of Apis mellifica extract on different hematology, biochemistry and histopathology parameters in rabbits for determining its safety and efficacy.Method: Hematological, biochemical investigations, urine analysis and histopathological studies were carried out on rabbits after the administration of the low dose of A. mellifica extract for a period of three months.Results: Our studies revealed gender wise difference in the result of hematology, lipid profile, liver enzymes and kidney function test except for the raised white blood cells, platelet levels, serum calcium, CPK, CK-MB, triglycerides, VLDL, direct bilirubin in both groups. Histopathology of stomach and kidney tissues revealed no toxicity as compared to the control group whereas; slight toxicity was observed in liver and heart tissues.Conclusion: Our research work revealed the significance of carrying out blood, biochemical and histo-pathological investigations to study the effects produced by low dose of A. mellifica administered for the long time. Partial protective effects of A. mellifica extract observed may be due to potent anti-oxidant and anti-inflammatory properties of its active constituents.Â
Authors and Affiliations
Mehjabeen . , Farah Saeed, Noor Jahan, Mansoor Ahmad
Keywords
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