Effects of Anabolic Androgenic Steroids on Renal Morphology in Rats
Journal Title: Archives of Renal Diseases and Management - Year 2017, Vol 3, Issue 2
Abstract
Aim: To investigate the long-term effects of anabolic androgenic steroids (AAS) on renal status in rats. Methods: Twenty Wistar rats were distributed into 2 groups: AAS or placebo, for 3 months. The animal received 10mg/kg body weight of Stanozonol once a week by intramuscular injection in the gluteus, or saline solution as placebo. Results: Urinary pH was more acidic in the AAS compared to the placebo group (p<0.05). Kidney weight was 15% higher in the AAS compared to the placebo group (p<0.001). Renal glomerular area was 12% higher in the AAS compared to the placebo group (p=0.001). Animals injected with AAS also displayed a no significant but clinically relevant ~20% higher kidney interstitial connective tissue, glomerular tufts and mesangiums. Conclusion: Overall, AAS negatively affected urinary pH and kidney morphology leading to a worse renal status. More attention should be taken to the use of AAS among populations at high risk for kidney disease.
Authors and Affiliations
Aparicio Virginia A, Camiletti-Moirón Daniel, Tassi Mohammed, Nebot Elena, de-Teresa Carlos, Aranda Pilar
Keywords
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- EP ID EP343529
- DOI 10.17352/2455-5495.000024
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