Effects of Anticonvulsant Retigabine on Pain Hypersensitivity Diabetic Rats with Neuropathy
Journal Title: INTERNATIONAL JOURNAL OF SCIENTIFIC STUDY - Year 2018, Vol 5, Issue 11
Abstract
Background: Diabetes is a chronic condition that affects millions of the world population. One of the most serious complications of diabetes is a neuropathic pain (pain due to nerve injury/dysfunction) that affects about 30–55% of diabetic patients. This nerve dysfunction can lead to numbness, weakness, and spontaneous/ongoing (stimulus independent) pain, and stimulus-evoked (allodynia and hyperalgesia) pain. This pain hypersensitivity is believed to be due to neuronal hyperexcitability. However, the mechanism of this neuronal hyperexcitability is unknown. Aims: Therefore, the aim of this research work was to examine the hypothesis that a subtype of K+ channels known as Kv7 channels (that play an important role in controlling hyperexcitability) is involved in the pathophysiology of diabetic neuropathy. Methods and Results: To examine this hypothesis, we use Darat model of diabetic neuropathic pain (DNP), known as streptozotocin (STZ) model (which involves an injection of 60 mg/kg of STZ; i.p), STZ is a toxin to pancreaticβ-cells that release insulin. We used this model to examine the effects of activating KV7 channels with retigabine (10 mg/kg) on behavioral signs of mechanical allodynia and heat hyperlagisa in the diabetic (STZ treated) rats. Our results show that retigabine (as elective KV7 channel activator that has recently been licensed for treating partial-onset seizures (epilepsy), which, like DNP, is characterized by neuronal hyperexcitability) significantly reduced both allodynia and hyperalgesia. Conclusions: These findings indicate that retigabine may represent a potential therapeutic alternative for DNP. However, further investigations are needed because of the small number of animals tested.
Authors and Affiliations
Marwan Abdulrhman Alshaikh Husian, Mohammed Salman Alnajjad, Marwan Ahmad Alrayhan, Hamzah Mohammed Alarfaj, Abdulrhman Mohammed Aljoher, Mohammed Abdulrhman Alshaikh Husian
Keywords
Related Articles
- EP ID EP477384
- DOI -
- Views 143
- Downloads 0
A Study on Surgical Management of Carcinoma Stomach
Introduction: Cancer is known as one of the major causes leading to many disorders, death, and disabilities worldwide. Among all organ cancers, gastrointestinal tract cancers present an interesting pattern in distributio...
Magnetic Resonance Imaging Evaluation of Brain in Developmental Delay Children
Introduction: Developmental delay is termed as gross or significant delay in more than one developmental domains.Aetiology of the developmental delay is the wide spectrum. MRI is the best modality to evaluate such childr...
Mandibular Ramus: An Indicator for Gender Determination - A Digital Radiographic Study
Aims and Objectives: The objectives of this study were as follows: (1) To measure, compare, and evaluate the various measurements of mandibular ramus as observed on orthopantomographs and (2) to assess the usefulness of...
Clinical Study on Prophylactic and Therapeutic Management of Thrombophilia in Adverse Pregnancy Outcome Patients
Background: There is a growing view that inherited and acquired thrombophilia may predispose to adverse pregnancy outcome (APO). APOs such as pregnancy loss, preeclampsia, and intrauterine growth retardation (IUGR) are a...
Study of Social and Cognitive Functioning in Children with Congenital Adrenal Hyperplasia
Background: Congenital adrenal hyperplasia (CAH) is a genetic problem of steroidogenesis in adrenals. Due to a particular enzyme deficiency causing lack of steroids, negative feedback involving hypothalamic-pituitary-adr...