Effects of Application of Chlorpyrifos Ethyl and Rose Water on Rat Pancreas
Journal Title: International Invention of Scientific Journal - Year 2018, Vol 2, Issue 4
Abstract
This study was conducted to detect preventive effects of rose water against toxicological effects of chlorpyrifos-ethyl. Group I was control group, group II was chlorpyrifos-ethyl (CPE) group (0.3 mg/kg/day), group III was water solution of rose extract (WR) group (100 mg/kg/day) while group IV was water solution of rose extract + chlorpyrifos-ethyl group (WR+CPE). The rats were sacrificed after fifteen days of experiment to collect blood samples. The results showed that comparing to the CPE group, there was a significant (p<0.001) decrease in the malondialdehyde (MDA) and total oxidant capacity (TOC) levels and a significant (p<0.001) increase in the total antioxidant capacity (TAC) and insulin levels in the CPE+GS group. Between the control and WR groups, insulin, WBC, catalase (CAT), lipase and amylase levels were significantly (p<0.001) higher, while TOC and OSI levels were significantly (p<0.001) lower in the WR group. The highest OSI levels were determined in the CPE group followed by CPE+RW (1.02 μmol H2O2 equ. /L), control (0.93 μmol H2O2 equ. /L) and RW (0.87 μmol H2O2 equ. /L) groups. In conclusion, it can be said that WR showed positive effects on the enzymes of pancreas and hematological parameters in rats, and it reduced in toxic effects of CPE.
Authors and Affiliations
Assist. Prof. Dr. Mumin Polat
Keywords
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