EFFECTS OF ARTIFICIAL SWEETENER(ASPARTAME) ON THE WEIGHT OF IMMUNE ORGANS AND GRANULOCYTES CELLS IN RATS
Journal Title: World Journal of Pharmaceutical Research - Year 2019, Vol 8, Issue 9
Abstract
This study aimed to determine the effect of aspartame on the white blood cells. Used for this study 24 adult male rats and 24 adult female rats, with age of 65-70 day, almost on an average live weight between (185-200) g. The experiment has concentrated on the daily dose, where the animals were randomly divided into two groups, each group contains 12animals females. the first, control groupdosed with 1ml physiologic solution daily, the second group gavage with concentrated aspartame (54 mg/kg/per day). The all groups had their daily dosages through the 75 day, and the experiment continued from October 2015- January 2016. After the dosage’s period has been completed, hematological samples have been taken from the rats to examine the count of neutrophils cells and isolation of spleen, thymus and lymph nodes to estimate the weight of it. The results showed there was significant decrease(P<0.05) in theneutrophil count, however no significant differences in monocyte and eosinophil count among groups, compared with the control group. Also showed that the weights of spleen, thymus and lymph nodes in aspartame treated animals were significantly decreased compared to control animals.
Authors and Affiliations
Ali Nayyef Umayra
Keywords
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